| Fabrication and properties of capsicum extract-loaded PVA and CA nanofiber patches. | |
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MedLine Citation:
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PMID: 23033938 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The aim of this study was to prepare, characterize and evaluate electrospun polyvinyl alcohol (PVA) and cellulose acetate (CA) nanofibers loaded with capsicum extract (CE) for use in topical skin treatments. CE, 0.5, 1 or 2 wt %, was loaded into PVA and CA electrospun fiber mats. Various properties of the CE-loaded fiber mats as well as release and skin permeation were investigated. The average diameters of these fibers ranged from 251-368 nm. The release rate of capsaicin from CE-loaded as-spun PVA was faster than that of the CA fiber mats and increased as the CE content in CE-loaded as-spun PVA and CA increased. The release kinetics of the CA and PVA fibers followed the Higuchi equation. The percentages of CE that permeated the shed snake skin with PVA and CA fiber mats containing 2 wt % CE after 24 h were 60% and 20%, respectively. The results suggest a potential use of PVA and CA nanofibers being used to control skin permeation of capsicum extract. Our research suggests the potential application of CE-loaded PVA electrospun mats as transdermal drug delivery systems. |
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Authors:
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Praneet Opanasopit; Warisada Sila-On; Theerasak Rojanarata; Tanasait Ngawhirunpat |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-4 |
Journal Detail:
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Title: Pharmaceutical development and technology Volume: - ISSN: 1097-9867 ISO Abbreviation: Pharm Dev Technol Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9610932 Medline TA: Pharm Dev Technol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Pharmaceutical Development of Green Innovations Group (PDGIG), Faculty of Pharmacy, Silpakorn University , Nakhon Pathom , Thailand. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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