Document Detail


Fabrication of a novel impedance cell sensor based on the polystyrene/polyaniline/Au nanocomposite.
MedLine Citation:
PMID:  19782222     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gold nanoparticles (AuNPs) were assembled on the surface of polystyrene (PS) and polyaniline (PANI) core-shell nanocomposite (PS@PANI) for the immobilization of HL-60 leukemia cells to fabricate a cell electrochemical sensor. The immobilized cells exhibited irreversible voltammetric response and increased the electron transfer resistance with a good correlation to the logarithmic value of concentration ranging from 1.6 x 10(3) to 1.6 x 10(8) cells mL(-1) with a limit of detection of 7.3 x 10(2) cells mL(-1) at 10 sigma. This biosensor was simple, low cost and disposable, which implied that the PS@PANI/Au composites can regard as the potential applications for clinical applications.
Authors:
Miaomiao Gu; Jingjing Zhang; Ye Li; Liping Jiang; Jun-Jie Zhu
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-07-04
Journal Detail:
Title:  Talanta     Volume:  80     ISSN:  1873-3573     ISO Abbreviation:  Talanta     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-09-28     Completed Date:  2010-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984816R     Medline TA:  Talanta     Country:  England    
Other Details:
Languages:  eng     Pagination:  246-9     Citation Subset:  IM    
Affiliation:
Key Lab of Analytical Chemistry for Life Science (MOE), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR China.
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MeSH Terms
Descriptor/Qualifier:
Aniline Compounds / chemistry*
Biosensing Techniques / instrumentation,  methods*
Cells, Immobilized
Electric Impedance
Electrochemistry
Electrodes
Gold / chemistry*
HL-60 Cells
Humans
Microscopy, Electron, Scanning
Microscopy, Electron, Transmission
Nanocomposites / chemistry*,  ultrastructure
Polystyrenes / chemistry*
Chemical
Reg. No./Substance:
0/Aniline Compounds; 0/Polystyrenes; 0/polyaniline; 7440-57-5/Gold

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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