Document Detail


Fabrication of holographic diffractive optical elements for enhancing light collection from fluorescence-based biochips.
MedLine Citation:
PMID:  19015685     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An approach to enhancing the light collection from fluorescence emitters bound on the surface of a biochip is presented. It is based on the integration of diffractive optical elements on the underside of the chip that are essentially thick volume holograms written into a layer of photopolymer recording material. The high diffractive efficiency and angular selectivity of these types of diffractive elements make them very effective collectors of the spatially anisotropic light emitted by surface-bound fluorophores. The holographic lithography setup used to fabricate the diffractive elements is described. Results obtained using both a focused laser and light from a fluorescence spot to characterize the performance of the diffractive optical elements are presented.
Authors:
Peter Macko; Maurice P Whelan
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Optics letters     Volume:  33     ISSN:  0146-9592     ISO Abbreviation:  Opt Lett     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-18     Completed Date:  2009-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708433     Medline TA:  Opt Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2614-6     Citation Subset:  IM    
Affiliation:
Nanotechnology and Molecular Imaging Unit, Institute for Health and Consumer Protection, European Commission-DG Joint Research Centre, Ispra, Italy. peter.macko@jrc.it
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MeSH Terms
Descriptor/Qualifier:
Equipment Design
Equipment Failure Analysis
Holography / instrumentation*
Image Enhancement / instrumentation*
Microscopy, Fluorescence / instrumentation*
Oligonucleotide Array Sequence Analysis / instrumentation*
Protein Array Analysis / instrumentation*
Refractometry / instrumentation*
Sensitivity and Specificity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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