| Fabrication and characterization of an inorganic gold and silica nanoparticle mediated drug delivery system for nitric oxide. | |
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MedLine Citation:
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PMID: 20610873 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nitric oxide (NO) plays an important role in inhibiting the development of hepatic fibrosis and its ensuing complication of portal hypertension by inhibiting human hepatic stellate cell (HSC) activation. Here we have developed a gold nanoparticle and silica nanoparticle mediated drug delivery system containing NO donors, which could be used for potential therapeutic application in chronic liver disease. The gold nanoconjugates were characterized using several physico-chemical techniques such as UV-visible spectroscopy and transmission electron microscopy. Silica nanoconjugates were synthesized and characterized as reported previously. NO released from gold and silica nanoconjugates was quantified under physiological conditions (pH = 7.4 at 37 degrees C) for a substantial period of time. HSC proliferation and the vascular tube formation ability, manifestations of their activation, were significantly attenuated by the NO released from these nanoconjugates. This study indicates that gold and silica nanoparticle mediated drug delivery systems for introducing NO could be used as a strategy for the treatment of hepatic fibrosis or chronic liver diseases, by limiting HSC activation. |
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Authors:
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Amitava Das; Priyabrata Mukherjee; Sumit K Singla; Praveen Guturu; Megan C Frost; Debabrata Mukhopadhyay; Vijay H Shah; Chitta Ranjan Patra |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-07-08 |
Journal Detail:
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Title: Nanotechnology Volume: 21 ISSN: 1361-6528 ISO Abbreviation: Nanotechnology Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-28 Completed Date: 2011-02-15 Revised Date: 2012-05-17 |
Medline Journal Info:
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Nlm Unique ID: 101241272 Medline TA: Nanotechnology Country: England |
Other Details:
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Languages: eng Pagination: 305102 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Proliferation
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drug effects Drug Delivery Systems / methods* Endocytosis / drug effects Gold / chemistry* Hepatic Stellate Cells / cytology, drug effects, metabolism, ultrastructure Humans Kinetics Metal Nanoparticles / chemistry*, ultrastructure Nanomedicine / methods Neovascularization, Physiologic / drug effects Nitric Oxide / administration & dosage* Nitric Oxide Donors / pharmacology Phenotype S-Nitroso-N-Acetylpenicillamine / pharmacology Silicon Dioxide / chemistry* Spectrophotometry, Ultraviolet |
| Grant Support | |
ID/Acronym/Agency:
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P30 DK 084567/DK/NIDDK NIH HHS; R01 DK 59615/DK/NIDDK NIH HHS; R01 DK059615/DK/NIDDK NIH HHS; R01 DK059615-09/DK/NIDDK NIH HHS; R01 HL 86990/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Nitric Oxide Donors; 10102-43-9/Nitric Oxide; 7440-57-5/Gold; 7631-86-9/Silicon Dioxide; 79032-48-7/S-Nitroso-N-Acetylpenicillamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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