| Fabrication of a PLGA-collagen peripheral nerve scaffold and investigation of its sustained release property in vitro. | |
| | |
MedLine Citation:
|
PMID: 17701295 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This study deals with the fabrication of a peripheral nerve scaffold prepared with poly (lactic acid-co-glycolic acid) [PLGA] and acellularized pigskin collagen micro particles and the investigation of its sustained release property in vitro. We took bovine serum albumin [BSA] as model drug to investigate the sustained-release property of the scaffold in vitro. The results showed the scaffold could release BSA steadily with a rate of 6.6 ng/d (r=0.994) or so. In a 1-month test period, the accumulative release ratio of BSA from the scaffold was up to 43%, and the shape of the scaffold was still originally well kept. In addition, the scaffold outcome non-immunogenicity, good cell adhesion and biodegradability. The results indicated a scaffold constructed by this technique would be a potential implanting support with prolonged sustained release function, such as for the use of nerve scaffold. |
| | |
Authors:
|
Bin Liu; Shao-Xi Cai; Kai-Wang Ma; Zhi-Ling Xu; Xiao-Zhen Dai; Li Yang; Cai Lin; Xiao-Bing Fu; K L Paul Sung; Xiao-Kun Li |
Related Documents
:
|
12195 - Enhancement of the antiplaque value of antibacterial agents through enamel-conditioning... 14653285 - The effect of antimicrobial pre-treatments on the performance of resin composite restor... 22257295 - Sialylation-independent mechanism involved in the amelioration of murine immune thrombo... 2400765 - Potential dental effects of infants' fruit drinks studied in vitro. 22251075 - Effect of season on heavy metal contents and chemical compositions of chub mackerel (sc... 18952245 - Detection of divinyl ether synthase in lily-of-the-valley (convallaria majalis) roots. |
Publication Detail:
|
Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-08-15 |
Journal Detail:
|
Title: Journal of materials science. Materials in medicine Volume: 19 ISSN: 0957-4530 ISO Abbreviation: J Mater Sci Mater Med Publication Date: 2008 Mar |
Date Detail:
|
Created Date: 2008-02-29 Completed Date: 2008-07-03 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9013087 Medline TA: J Mater Sci Mater Med Country: United States |
Other Details:
|
Languages: eng Pagination: 1127-32 Citation Subset: IM |
Affiliation:
|
College of Bioengineering, Chongqing University, Chongqing, 400044, P.R. China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Behavior, Animal / drug effects Cell Adhesion / drug effects Cell-Free System / drug effects, ultrastructure Cells, Cultured Collagen / chemistry* Delayed-Action Preparations / administration & dosage, pharmacokinetics Drug Carriers / chemical synthesis*, pharmacokinetics* Extracellular Matrix / chemistry, ultrastructure Female Lactic Acid / chemistry* Male Microspheres Nerve Regeneration / drug effects, physiology Peripheral Nerves* / drug effects, physiology Polyglycolic Acid / chemistry* Rabbits Serum Albumin, Bovine / administration & dosage, pharmacokinetics Tissue Scaffolds* / chemistry |
| Chemical | |
Reg. No./Substance:
|
0/Delayed-Action Preparations; 0/Drug Carriers; 0/Serum Albumin, Bovine; 0/polylactic acid-polyglycolic acid copolymer; 26009-03-0/Polyglycolic Acid; 50-21-5/Lactic Acid; 9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Preparation of chitosan-hyaluronate double-walled microspheres by emulsification-coacervation method...
Next Document: The construction and characterization of layered double hydroxides as delivery vehicles for podophyl...