Document Detail


Fabrication of a PLGA-collagen peripheral nerve scaffold and investigation of its sustained release property in vitro.
MedLine Citation:
PMID:  17701295     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study deals with the fabrication of a peripheral nerve scaffold prepared with poly (lactic acid-co-glycolic acid) [PLGA] and acellularized pigskin collagen micro particles and the investigation of its sustained release property in vitro. We took bovine serum albumin [BSA] as model drug to investigate the sustained-release property of the scaffold in vitro. The results showed the scaffold could release BSA steadily with a rate of 6.6 ng/d (r=0.994) or so. In a 1-month test period, the accumulative release ratio of BSA from the scaffold was up to 43%, and the shape of the scaffold was still originally well kept. In addition, the scaffold outcome non-immunogenicity, good cell adhesion and biodegradability. The results indicated a scaffold constructed by this technique would be a potential implanting support with prolonged sustained release function, such as for the use of nerve scaffold.
Authors:
Bin Liu; Shao-Xi Cai; Kai-Wang Ma; Zhi-Ling Xu; Xiao-Zhen Dai; Li Yang; Cai Lin; Xiao-Bing Fu; K L Paul Sung; Xiao-Kun Li
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-15
Journal Detail:
Title:  Journal of materials science. Materials in medicine     Volume:  19     ISSN:  0957-4530     ISO Abbreviation:  J Mater Sci Mater Med     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-29     Completed Date:  2008-07-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9013087     Medline TA:  J Mater Sci Mater Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1127-32     Citation Subset:  IM    
Affiliation:
College of Bioengineering, Chongqing University, Chongqing, 400044, P.R. China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal / drug effects
Cell Adhesion / drug effects
Cell-Free System / drug effects,  ultrastructure
Cells, Cultured
Collagen / chemistry*
Delayed-Action Preparations / administration & dosage,  pharmacokinetics
Drug Carriers / chemical synthesis*,  pharmacokinetics*
Extracellular Matrix / chemistry,  ultrastructure
Female
Lactic Acid / chemistry*
Male
Microspheres
Nerve Regeneration / drug effects,  physiology
Peripheral Nerves* / drug effects,  physiology
Polyglycolic Acid / chemistry*
Rabbits
Serum Albumin, Bovine / administration & dosage,  pharmacokinetics
Tissue Scaffolds* / chemistry
Chemical
Reg. No./Substance:
0/Delayed-Action Preparations; 0/Drug Carriers; 0/Serum Albumin, Bovine; 0/polylactic acid-polyglycolic acid copolymer; 26009-03-0/Polyglycolic Acid; 50-21-5/Lactic Acid; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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