Document Detail


Fabrication of Hollow and Porous Structured GdVO4:Dy3+ Nanospheres as Anti-cancer Drug Carrier and MRI Contrast Agent.
MedLine Citation:
PMID:  23281806     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Hollow and porous structured GdVO4:Dy3+ spheres were fabricated via a facile self-sacrificing templated method. The large cavity allows them to be used as potential hosts for therapeutic drugs, and the porous feature of the shell allows guest molecules to easily pass through the void space and surrounding environment. The samples show strong yellow-green emission of Dy3+ (485 nm, 4F9/2→6H15/2; 575 nm, 4F9/2→6H13/2) under UV excitation. The emission intensity of GdVO4:Dy3+ was weakened after encapsulation of anti-cancer drug (doxorubicin hydrochloride, DOX) and gradually restored with the cumulative released time of DOX. These hollow spheres were nontoxic to HeLa cells, while DOX-loaded samples led to apparent cytotoxicity as a result of the sustained release of DOX. ICP measurement indicates that free toxic Gd ions can hardly dissolate from the matrix. The endocytosis process of DOX-loaded hollow spheres is observed using confocal laser scanning microscopy (CLSM). Furthermore, GdVO4:Dy3+ hollow spheres can be used for T1-weighted magnetic resonance (MR) imaging. These results implicate that the luminescent GdVO4:Dy3+ spheres with hollow and porous structure are promising platforms for drug storage/release and MR imaging.
Authors:
Xiaojiao Kang; Dongmei Yang; Ping'an Ma; Yunlu Dai; Mengmeng Shang; Dongling Geng; Ziyong Cheng; Jun Lin
Related Documents :
24467436 - Arylamine n-acetyltransferases: from drug metabolism and pharmacogenetics to drug disco...
24286206 - Preparation, characterization and in vitro evaluation of sterically stabilized liposome...
23095256 - Pharmacophore-based drug design and biological evaluation of novel abcb1 inhibitors.
23358236 - Inhibition of p-glycoprotein mediated multidrug resistance by stemofoline derivatives.
6099486 - Characterization of prototypical opioid antagonists, agonist-antagonists, and agonists ...
9697076 - Antiprogestin pharmacodynamics, pharmacokinetics, and metabolism: implications for thei...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-3
Journal Detail:
Title:  Langmuir : the ACS journal of surfaces and colloids     Volume:  -     ISSN:  1520-5827     ISO Abbreviation:  Langmuir     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9882736     Medline TA:  Langmuir     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Randomized Phase II trial of paclitaxel and carboplatin followed by gemcitabine switch-maintenance t...
Next Document:  Fabrication and characterization of plasma-polymerized poly(ethylene glycol) film with superior bioc...