| FTO genotype is associated with exercise training-induced changes in body composition. | |
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MedLine Citation:
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PMID: 19543202 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The fat mass (FM) and obesity-associated (FTO) gene is the first obesity-susceptibility gene identified by genome-wide association scans and confirmed in several follow-up studies. Homozygotes for the risk allele (A/A) have 1.67 times greater risk of obesity than those who do not have the allele. However, it is not known whether regular exercise-induced changes in body composition are influenced by the FTO genotype. The purpose of our study was to test whether the FTO genotype is associated with exercise-induced changes in adiposity. Body composition was derived from underwater weighing before and after a 20-week endurance training program in 481 previously sedentary white subjects of the HERITAGE Family Study. FTO single-nucleotide polymorphism (SNP) rs8050136 was genotyped using Illumina GoldenGate assay. In the sedentary state, the A/A homozygotes were significantly heavier and fatter than the heterozygotes and the C/C homozygotes in men (P = 0.004) but not in women (P = 0.331; gene-by-sex interaction P = 0.0053). The FTO genotype was associated with body fat responses to regular exercise (P < 0.005; adjusted for age, sex, and baseline value of response trait): carriers of the C allele showed three times greater FM and %body fat losses than the A/A homozygotes. The FTO genotype explained 2% of the variance in adiposity changes. Our data suggest that the FTO obesity-susceptibility genotype influences the body fat responses to regular exercise. Resistance to exercise-induced reduction in total adiposity may represent one mechanism by which the FTO A allele promotes overweight and obesity. |
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Authors:
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Tuomo Rankinen; Treva Rice; Margarita Teran-Garcia; Dabeeru C Rao; Claude Bouchard |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-06-18 |
Journal Detail:
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Title: Obesity (Silver Spring, Md.) Volume: 18 ISSN: 1930-7381 ISO Abbreviation: Obesity (Silver Spring) Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-29 Completed Date: 2010-02-22 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 101264860 Medline TA: Obesity (Silver Spring) Country: United States |
Other Details:
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Languages: eng Pagination: 322-6 Citation Subset: IM |
Affiliation:
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Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA. rankint@pbrc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological
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genetics Adiposity / genetics* Adult African Americans / genetics Body Mass Index European Continental Ancestry Group / genetics Exercise* Female Gene Frequency Genetic Predisposition to Disease Heterozygote Homozygote Humans Male Obesity / ethnology, genetics*, physiopathology Phenotype Polymorphism, Single Nucleotide* Proteins / genetics* Risk Factors Sedentary Lifestyle Time Factors Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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HL-45670/HL/NHLBI NIH HHS; R01 HL045670-15/HL/NHLBI NIH HHS; R01 HL045670-16/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/FTO protein, human; 0/Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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