| FTO - Friend or foe? | |
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MedLine Citation:
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PMID: 19924617 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fat mass and obesity associated gene ( FTO) is the most relevant polygene for obesity to date. It has been identified by genome wide association studies concerning body weight regulation. However, its functional relevance for the pathogenesis of obesity remains elusive. Studies in rodents provide data pointing to a central role of FTO through regulation of food intake. In addition, peripheral effects of FTO are also discussed in the literature. This review highlights the possible relevance of FTO for weight regulation and obesity development in central and peripheral tissues with a special focus on adipose tissue. |
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Authors:
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D Tews; P Fischer-Posovszky; M Wabitsch |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-11-18 |
Journal Detail:
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Title: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et m?tabolisme Volume: 42 ISSN: 1439-4286 ISO Abbreviation: Horm. Metab. Res. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-04 Completed Date: 2010-04-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0177722 Medline TA: Horm Metab Res Country: Germany |
Other Details:
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Languages: eng Pagination: 75-80 Citation Subset: IM |
Copyright Information:
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Georg Thieme Verlag KG Stuttgart * New York. |
Affiliation:
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Department of Pediatrics and Adolescent Medicine, University of Ulm, Germany. daniel.tews@uniklinik-ulm.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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metabolism* Animals Body Weight / physiology* Humans Obesity / metabolism* Proteins / physiology* |
| Chemical | |
Reg. No./Substance:
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0/FTO protein, human; 0/Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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