Document Detail

FTIR spectroscopic analyses of human placental membranes.
MedLine Citation:
PMID:  11135189     Owner:  NLM     Status:  MEDLINE    
We investigated the differences in the Fourier transform infrared (FTIR) spectra of normal and abnormal human placentas. Normal placentas, placentas with infant intrauterine growth restriction (IUGR), and placentas from mothers with diabetes mellitus (DM) were used, none of which had been treated before measurement. The tissues were divided into three parts: the upper one-third portion (P1), the middle portion (P2), and the lower one-third portion (P3). Placental tissues were also investigated histochemically. The differences of the main second-derivative FTIR spectra among P1, P2, and P3 in normal placentas were observed in bands appearing between 1080 and 1090 cm(-1). Bands in P2 were observed at 1083 cm(-1), which was significantly higher than that in P3 (p < 0.05). The spectrum of P2 tissue in placentas with infant IUGR had a peak at 1081 cm(-1), which was significantly different from those of P1 and P3 (p < 0.05). In placentas with DM, the P2 band was shifted to a peak at 1088 cm(-1). These data were well correlated with the histochemical sugar-chain staining pattern of the P2 portion of the placenta. Our data suggested that this IR technique is applicable to the clinical diagnosis of diseases in the gynecological field.
Y Nishida; S Yoshida; H J Li; Y Higuchi; N Takai; I Miyakawa
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biopolymers     Volume:  62     ISSN:  0006-3525     ISO Abbreviation:  Biopolymers     Publication Date:  2001  
Date Detail:
Created Date:  2001-01-26     Completed Date:  2001-05-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372525     Medline TA:  Biopolymers     Country:  United States    
Other Details:
Languages:  eng     Pagination:  22-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Oita Medical University, Hasama-Machi, Oita 879-5593, Japan.
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MeSH Terms
Fetal Growth Retardation / pathology*
Infant, Newborn
Membranes / anatomy & histology,  pathology
Placenta* / anatomy & histology,  pathology
Pregnancy in Diabetics / pathology
Spectroscopy, Fourier Transform Infrared*

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