Document Detail

FSH and testosterone signaling in Sertoli cells.
MedLine Citation:
PMID:  15985628     Owner:  NLM     Status:  MEDLINE    
Testosterone and follicle-stimulating hormone (FSH) are required to obtain full reproductive potential. In the testis, somatic Sertoli cells transduce signals from testosterone and FSH into the production of factors that are required by germ cells as they mature into spermatozoa. Recent advances in identifying new signaling pathways that are regulated by FSH and testosterone have allowed for refinement in the understanding of the independent, overlapping and synergistic actions of these hormones. In this review, we discuss the signaling pathways that are regulated by FSH and testosterone as well as the resulting metabolic and gene expression changes that occur as related to Sertoli cell proliferation, differentiation and the support of spermatogenesis.
William H Walker; Jing Cheng
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Reproduction (Cambridge, England)     Volume:  130     ISSN:  1470-1626     ISO Abbreviation:  Reproduction     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-06-29     Completed Date:  2005-12-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100966036     Medline TA:  Reproduction     Country:  England    
Other Details:
Languages:  eng     Pagination:  15-28     Citation Subset:  IM    
Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
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MeSH Terms
1-Phosphatidylinositol 3-Kinase / metabolism
Calcium / metabolism
Cyclic AMP-Dependent Protein Kinases / metabolism
Follicle Stimulating Hormone / metabolism*
Gene Expression Regulation
Receptors, FSH / metabolism
Sertoli Cells / cytology,  metabolism*
Signal Transduction / physiology*
Testosterone / metabolism*
Grant Support
Reg. No./Substance:
0/Receptors, FSH; 58-22-0/Testosterone; 7440-70-2/Calcium; 9002-68-0/Follicle Stimulating Hormone; EC 3-Kinase; EC AMP-Dependent Protein Kinases

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