Document Detail

FSH isoform composition of commercial gonadotrophin preparations: a neglected aspect?
MedLine Citation:
PMID:  15333258     Owner:  NLM     Status:  MEDLINE    
The clinical efficacy of commercial gonadotrophin preparations has been the subject of an intense debate during recent years. Arguments have primarily focused on the origin of FSH activity (urine versus recombinant derived) and whether the preparation included LH-like activity. FSH isoform composition has received little or no attention, and is usually considered to have negligible effect on clinical effectiveness. By presenting the available data on the FSH isoform composition of commercial gonadotrophin preparations, the present paper challenges this assumption. To evaluate whether the FSH isoform composition affected the efficacy of a product, a meta-analysis was performed that compared a preparation expressing an acidic isoform profile (urinary-derived Metrodin-HP) with a preparation rich in less acidic isoforms (recombinant derived Gonal F). A total of five randomized clinical trials that specifically compared these two preparations was identified and included in the analysis. All parameters relating to the direct effect of FSH on the follicle differed significantly in favour of the product rich in less acidic isoforms, while data on pregnancy outcome did not reach significance. The importance of the FSH isoform profile and whether the FSH is derived from urine or by recombinant technique is discussed in relation to clinical efficacy. It is suggested that the FSH isoform profile of commercial gonadotrophin preparations is of clinical importance and should be taken into account when evaluating efficacy.
Claus Yding Andersen; Lars Grabow Westergaard; Madelon van Wely
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  9     ISSN:  1472-6483     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-08-30     Completed Date:  2005-01-31     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  England    
Other Details:
Languages:  eng     Pagination:  231-6     Citation Subset:  IM    
Laboratory of Reproductive Biology, Section 5712, University Hospital of Copenhagen, DK-2100 Copenhagen, Denmark.
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MeSH Terms
Carbohydrates / chemistry
Clinical Trials as Topic
Fertility Agents, Female / chemistry
Fertilization in Vitro / methods*
Follicle Stimulating Hormone / chemistry*
Follicle Stimulating Hormone, Human / chemistry
Gonadotropins / chemistry
Menotropins / chemistry
Peptides / chemistry
Pregnancy Outcome
Protein Isoforms
Quality Control
Recombinant Proteins / chemistry
Reg. No./Substance:
0/Carbohydrates; 0/Fertility Agents, Female; 0/Follicle Stimulating Hormone, Human; 0/Gonadotropins; 0/Peptides; 0/Protein Isoforms; 0/Recombinant Proteins; 61489-71-2/Menotropins; 9002-68-0/Follicle Stimulating Hormone

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