| FSAP, a new player in inflammation? | |
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MedLine Citation:
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PMID: 22252569 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Factor VII-activating protease (FSAP) is a serine protease in plasma that has a role in coagulation and fibrinolysis. FVII could be activated by purified FSAP in a tissue factor independent manner and pro-urokinase has been demonstrated to be a substrate for purified FSAP in-vitro. However, the physiological role of FSAP in haemostasis remains unclear. More recently FSAP is suggested to be involved in inflammation. It modulates vascular permeability directly and indirectly by the generation of bradykinin. Furthermore, FSAP is activated by dead cells induced by the inflammatory response and subsequently removes nucleosomes from apoptotic cells. FSAP activation can be detected in sepsis patients as well. However, whether FSAP activation upon inflammation is beneficial or detrimental remains an open question. In this review the structure, activation mechanisms and the possible role of FSAP in inflammation are discussed. |
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Authors:
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F Stephan; L A Aarden; S Zeerleder |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hämostaseologie Volume: 32 ISSN: 0720-9355 ISO Abbreviation: Hamostaseologie Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8204531 Medline TA: Hamostaseologie Country: Germany |
Other Details:
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Languages: eng Pagination: 51-5 Citation Subset: IM |
Affiliation:
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Sacha Zeerleder, MD PhD, Department of Immunopathology, Sanquin Research, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands, Tel. +31/205 12 31 71, Fax +31/205 12 31 70, E-mail: s.zeerleder@sanquin.nl. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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