Document Detail

FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts.
MedLine Citation:
PMID:  15094036     Owner:  NLM     Status:  MEDLINE    
FRS2alpha and FRS2beta, two members of the FRS2 family of docking proteins, become tyrosine phosphorylated in response to fibroblast growth factor (FGF) or nerve growth factor (NGF) stimulation. Tyrosine phosphorylated FRS2alpha serves as a platform for the recruitment of multiple signaling proteins for activation of the Ras-mitogen-activated protein (MAP) kinase signaling cascade. We report that Frs2alpha and Frs2beta have distinct spatio-temporal expression patterns in mouse embryos. We further show that FRS2beta can compensate for the loss of FRS2alpha for activation of MAP kinase when expressed in fibroblasts from Frs2alpha(-/-) mouse embryos. We propose that the FRS2 family proteins have distinct roles in vivo through activation of common signaling proteins including MAP kinase.
Noriko Gotoh; Shaked Laks; Misako Nakashima; Irit Lax; Joseph Schlessinger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEBS letters     Volume:  564     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-19     Completed Date:  2004-06-03     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  14-8     Citation Subset:  IM    
Department of Pharmacology, Yale University School of Medicine, Sterling Hall of Medicine, 333 Cedar Street, B-204, New Haven, CT 06520, USA.
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MeSH Terms
Adaptor Proteins, Signal Transducing*
Carrier Proteins / genetics,  metabolism,  physiology*
Embryo, Mammalian
Fibroblasts / metabolism
Gene Expression Regulation, Developmental
Intracellular Signaling Peptides and Proteins*
Lipoproteins / genetics,  metabolism,  physiology*
Mice, Knockout
Mitogen-Activated Protein Kinases / metabolism*
Protein Binding
RNA, Messenger / analysis,  biosynthesis*
Signal Transduction
Time Factors
Tissue Distribution
Reg. No./Substance:
0/Adaptor Proteins, Signal Transducing; 0/Carrier Proteins; 0/FRS3 protein, human; 0/Frs3 protein, mouse; 0/Intracellular Signaling Peptides and Proteins; 0/Lipoproteins; 0/RNA, Messenger; EC Protein Kinases

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