| FR182876, a new microtubule modulator with high water-solubility, from a Streptomyces. | |
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MedLine Citation:
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PMID: 15376555 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the course of seeking new anti-tumor drugs, a new microtubule modulator with high water-solubility, FR182876, was isolated from a Streptomyces which also produces FR182877. Even modern spectroscopic methods could not solve the structure of FR182876 due to its structural complexity and chemical instability. Thus, we have combined chemical correlations with spectroscopic methods and determined its structure, which features a highly fused ring system and 3-methylhistidine. The latter is believed to contribute to both solubility in water and activity in promoting tubulin polymerization. FR182876 showed potent cytotoxicity against a panel of cancer cells at concentrations of 28-75 ng/ml. |
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Authors:
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Seiji Yoshimura; Bunji Sato; Shigehiro Takase; Hiroshi Terano |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of antibiotics Volume: 57 ISSN: 0021-8820 ISO Abbreviation: J. Antibiot. Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-09-20 Completed Date: 2004-10-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0151115 Medline TA: J Antibiot (Tokyo) Country: Japan |
Other Details:
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Languages: eng Pagination: 429-35 Citation Subset: IM |
Affiliation:
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Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5-2-3, Tokodai, Tsukuba 300-2698, Japan. seiji_yoshimura@po.fujisawa.co.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibiotics, Antineoplastic
/
chemistry,
isolation & purification*,
pharmacology Cell Line, Tumor Heterocyclic Compounds with 4 or More Rings / chemistry, isolation & purification*, pharmacology Humans Microtubules / drug effects* Solubility Streptomyces / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Antibiotics, Antineoplastic; 0/FR 182876; 0/Heterocyclic Compounds with 4 or More Rings |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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