Document Detail


Nociceptin/orphanin FQ contributes to hypoxic/ischemic impairment of hypercapnic cerebrovasodilation.
MedLine Citation:
PMID:  11543945     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous studies in piglets show that hypercapnic pial artery dilation was blunted following cerebral ischemia. Unrelated studies show that the newly described opioid nociceptin orphanin FQ (NOC/oFQ) is released into cerebrospinal fluid and contributes to altered cerebral hemodynamics following hypoxia/ischemia. This study was designed to determine the contribution of NOC/oFQ to hypoxic/ischemic impairment of hypercapnic pial dilation in piglets equipped with a closed cranial window. Global cerebral ischemia was produced via elevated intracranial pressure. Hypoxia decreased P(O2) to 34 +/- 3 mmHg. Topical NOC/oFQ (10(-10) M), the CSF concentration following hypoxia/ischemia, had no effect on pial artery diameter by itself but attenuated hypercapnia P(CO2) of (73 +/- 2 mmHg)-induced pial artery dilation (28 +/- 2 vs. 19 +/- 2%). Hypercapnia pial artery dilation was blunted by hypoxia/ischemia but such dilation was partially protected by pretreatment with the putative NOC/oFQ receptor antagonist, [F/G] NOC/oFQ (1-13) NH(2) (10(-6) M), (25 +/- 1, sham control; 4 +/- 1, hypoxia/ischemia; and 12 +/- 3%, hypoxia/ischemia + [F/G] NOC/oFQ (1-13) NH(2), respectively). These data suggest that NOC/oFQ release contributes to impaired hypercapnia-induced cerebrovasodilation following hypoxia/ischemia.
Authors:
A Jagolino; W M Armstead
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research bulletin     Volume:  55     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-09-06     Completed Date:  2001-10-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  United States    
Other Details:
Languages:  eng     Pagination:  465-8     Citation Subset:  IM    
Affiliation:
Department of Anesthesia, University of Pennsylvania, Philadelphia, PA 19104, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Blood Gas Analysis
Blood Pressure
Cerebrovascular Circulation / physiology
Female
Hypercapnia / metabolism*
Hypoxia-Ischemia, Brain / metabolism*
Male
Opioid Peptides / metabolism*
Pia Mater / blood supply
Swine
Vasodilation / physiology*
Chemical
Reg. No./Substance:
0/Opioid Peptides; 0/nociceptin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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