Document Detail

Nociceptin/orphanin FQ contributes to hypoxic/ischemic impairment of hypercapnic cerebrovasodilation.
MedLine Citation:
PMID:  11543945     Owner:  NLM     Status:  MEDLINE    
Previous studies in piglets show that hypercapnic pial artery dilation was blunted following cerebral ischemia. Unrelated studies show that the newly described opioid nociceptin orphanin FQ (NOC/oFQ) is released into cerebrospinal fluid and contributes to altered cerebral hemodynamics following hypoxia/ischemia. This study was designed to determine the contribution of NOC/oFQ to hypoxic/ischemic impairment of hypercapnic pial dilation in piglets equipped with a closed cranial window. Global cerebral ischemia was produced via elevated intracranial pressure. Hypoxia decreased P(O2) to 34 +/- 3 mmHg. Topical NOC/oFQ (10(-10) M), the CSF concentration following hypoxia/ischemia, had no effect on pial artery diameter by itself but attenuated hypercapnia P(CO2) of (73 +/- 2 mmHg)-induced pial artery dilation (28 +/- 2 vs. 19 +/- 2%). Hypercapnia pial artery dilation was blunted by hypoxia/ischemia but such dilation was partially protected by pretreatment with the putative NOC/oFQ receptor antagonist, [F/G] NOC/oFQ (1-13) NH(2) (10(-6) M), (25 +/- 1, sham control; 4 +/- 1, hypoxia/ischemia; and 12 +/- 3%, hypoxia/ischemia + [F/G] NOC/oFQ (1-13) NH(2), respectively). These data suggest that NOC/oFQ release contributes to impaired hypercapnia-induced cerebrovasodilation following hypoxia/ischemia.
A Jagolino; W M Armstead
Related Documents :
4316225 - Effect of acute hypoxia on vascular responsiveness in man. i. responsiveness to lower b...
2903135 - Absence of neural modulation of hypoxic pulmonary vasoconstriction in conscious dogs.
2297815 - Evidence for cholinergic regulation of microvessel hydraulic conductance during tissue ...
7435605 - Cerebral energy metabolism in mallard ducks during apneic asphyxia: the role of oxygen ...
3707805 - Changes in intracranial pressure associated with extradural anaesthesia.
11489025 - Are auditory warnings in the intensive care unit properly adjusted?
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research bulletin     Volume:  55     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-09-06     Completed Date:  2001-10-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  United States    
Other Details:
Languages:  eng     Pagination:  465-8     Citation Subset:  IM    
Department of Anesthesia, University of Pennsylvania, Philadelphia, PA 19104, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Animals, Newborn
Blood Gas Analysis
Blood Pressure
Cerebrovascular Circulation / physiology
Hypercapnia / metabolism*
Hypoxia-Ischemia, Brain / metabolism*
Opioid Peptides / metabolism*
Pia Mater / blood supply
Vasodilation / physiology*
Reg. No./Substance:
0/Opioid Peptides; 0/nociceptin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Noradrenaline synthesis, release and vesicular transport in the rat brain following subarachnoid hae...
Next Document:  Effect of nitric oxide donors on extracellular ATP, ADP, and AMP catabolism in rat hippocampal synap...