Document Detail


FOXOs and Sirtuins in Vascular Growth, Maintenance, and Aging.
MedLine Citation:
PMID:  22539757     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Blood vessels form the first organ in the developing embryo and build extensive networks that supply all cells with nutrients and oxygen throughout life. As blood vessels get older, they often become abnormal in structure and function, thereby contributing to numerous age-associated diseases including ischemic heart and brain disease, neurodegeneration, or cancer. First described as regulators of the aging process in invertebrate model organisms, Forkhead box "O" (FOXO) transcription factors and sirtuin deacetylases are now emerging as key regulators of mammalian vascular development and disease. The integration of individual FOXO and sirtuin family members into various aspects of vessel growth, maintenance, and function provides new perspectives on disease mechanisms of aging, the most important risk factor for medical maladies of the vascular system.
Authors:
Mark F Oellerich; Michael Potente
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation research     Volume:  110     ISSN:  1524-4571     ISO Abbreviation:  Circ. Res.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1238-51     Citation Subset:  IM    
Affiliation:
Vascular Epigenetics Group, Institute of Cardiovascular Regeneration, Center for Molecular Medicine and Department of Cardiology, Internal Medicine III, Goethe University, Theodor-Stern-Kai 7, D-60590, Frankfurt, Germany. potente@em.uni-frankfurt.de.
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