Document Detail


FOXO1 and c-jun transcription factors mRNA are modulated in endometriosis.
MedLine Citation:
PMID:  15501904     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Endometriosis is a polygenic gynaecological condition affecting 5-15% of women of childbearing age. Major symptoms of the disease are pelvic pain and infertility. No clear link has been established between symptoms and the stage of the disease. Although some aspects have begun to be clarified, clinical understanding of endometriosis remains partial at the molecular level. In this perspective, we targeted isolation of differentially expressed genes in the eutopic endometrial tissue. Our assumption was that the endometrial cells of patients presented an unusual gene expression profile, allowing their implantation and survival in an ectopic site, leading to endometriotic lesions. Here, we report that mRNA steady-state levels of two key transcription factors are modulated in endometriosis. FOXO1 (also known as FKHR) levels were 1.6-fold lower in endometriosis compared to the control group at the onset of the secretory phase (day 15-21), while c-jun mRNA was present at higher amounts in endometriosis (1.5-fold) at the proliferative phase of the menstrual cycle. These results were derived from a large sample composed of 157 control subjects and 209 patients with endometriosis. Gene profiling was conducted by real-time quantitative PCR, and data were quality controlled before statistical analysis. Whether protein levels are affected as well remains to be investigated.
Authors:
K Shazand; S Baban; C Privé; B Malette; P Croteau; M Lagacé; J-B Racine; P Hugo
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Publication Detail:
Type:  Journal Article     Date:  2004-10-22
Journal Detail:
Title:  Molecular human reproduction     Volume:  10     ISSN:  1360-9947     ISO Abbreviation:  Mol. Hum. Reprod.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-02     Completed Date:  2005-05-06     Revised Date:  2008-05-06    
Medline Journal Info:
Nlm Unique ID:  9513710     Medline TA:  Mol Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  871-7     Citation Subset:  IM    
Affiliation:
Metriogene Biosciences, Inc., Molecular Biology Unit, 6100, Royalmount Ave, Montreal, Quebec, H4P 2R2, Canada.
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MeSH Terms
Descriptor/Qualifier:
DNA-Binding Proteins / genetics*
Endometriosis / genetics*,  metabolism
Female
Forkhead Transcription Factors
Gene Expression Profiling
Gene Expression Regulation*
Humans
Menstrual Cycle / genetics
Proto-Oncogene Proteins c-jun / genetics*
RNA, Messenger / analysis,  metabolism
Transcription Factors / genetics*
Uterus / pathology
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/FOXO1 protein, human; 0/Forkhead Transcription Factors; 0/Proto-Oncogene Proteins c-jun; 0/RNA, Messenger; 0/Transcription Factors

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