| FOXO1 Expression and Regulation in Endometrial Tissue during the Menstrual Cycle and in Early Pregnancy Decidua. | |
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MedLine Citation:
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PMID: 22538365 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aims: To determine FOXO1 (forkhead box O1) expression in the human endometrium during the menstrual cycle and decidua of early pregnancy, as well as FOXO1 regulation in endometrial stromal cells (ESC). Methods: Immunohistochemistry, RT-qPCR, and Western blot analyses evaluated cellular localization and altered FOXO1 expression in the endometrium during the menstrual cycle and decidua of early pregnancy (proliferative phase, n = 12; early-secretory phase, n = 7; mid-secretory phase, n = 10; late-secretory phase, n = 10; early pregnancy, n = 12). Using RT-qPCR and Western blot, we studied the regulation of FOXO1 by 8-bromo-cAMP, 4-pregnene-3,20-dione, 17β-estradiol, and human chorionic gonadotrophin in ESC (n = 5). Results: The expression level of FOXO1 in human endometrial tissue fluctuated with the menstrual cycle. If pregnancy occurred, the expression of FOXO1 was further increased (p < 0.05) and cAMP regulated FOXO1 expression in ESC. In addition, 4-pregnene-3,20-dione cooperatively stimulated FOXO1 expression with cAMP. We also observed FOXO1 expression during in vitro cAMP-induced decidualization. Conclusions: The pattern of FOXO1 expression suggests a potential role for FOXO1 in implantation and decidualization. |
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Authors:
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Wei Fan; Shang-Wei Li; Wei-Hong Li; Yan Wang; Yan Gong; Qian-Hong Ma; San Luo |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-24 |
Journal Detail:
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Title: Gynecologic and obstetric investigation Volume: - ISSN: 1423-002X ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7900587 Medline TA: Gynecol Obstet Invest Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 S. Karger AG, Basel. |
Affiliation:
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Department of Obstetrics and Gynecology, Center of Reproductive Medicine, The West China Second University Hospital, Sichuan University, Sichuan, PR China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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