Document Detail

Forkhead homeobox type O transcription factors in the responses to oxidative stress.
MedLine Citation:
PMID:  20618067     Owner:  NLM     Status:  MEDLINE    
Reactive oxygen species (ROS) and cellular oxidative stress are involved in many physiological and pathophysiological processes, including cellular and organismal aging, migration, proliferation, senescence or death of normal and cancer cells, and stress resistance of stem cells. The forkhead homeobox type O (FOXO) transcription factors FOXO1, FOXO3a, and FOXO4 are critical mediators of the cellular responses to oxidative stress and have been implicated in many of the above ROS-regulated processes. In cancer cells they converge oxidative stress signaling to cell cycle arrest and cell death or promote a motile phenotype. Dependent on their posttranslational modifications FOXOs can also actively regulate the detoxification of cells from ROS and promote stress resistance. Thus, FOXO transcription factors are of vital importance in processes regulating tumor survival or progression, stem cell maintenance, age-related pathological processes, and lifespan extension.
Peter Storz
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2010-10-19
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  14     ISSN:  1557-7716     ISO Abbreviation:  Antioxid. Redox Signal.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-17     Completed Date:  2011-05-04     Revised Date:  2013-11-14    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  593-605     Citation Subset:  IM    
Department for Cancer Biology, Mayo Clinic, Jacksonville, Florida 32224, USA.
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MeSH Terms
Forkhead Transcription Factors / genetics,  metabolism*
Models, Biological
Oxidative Stress / genetics,  physiology*
Reactive Oxygen Species / metabolism*
Grant Support
P50 CA102701/CA/NCI NIH HHS; R01 CA140182/CA/NCI NIH HHS; R01 CA140182/CA/NCI NIH HHS; R21 CA135102/CA/NCI NIH HHS
Reg. No./Substance:
0/Forkhead Transcription Factors; 0/Reactive Oxygen Species

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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