Document Detail


A FORTRAN program for the design and analysis of sequential clinical trials.
MedLine Citation:
PMID:  3838715     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Clinical scientists are becoming increasingly aware of the need to monitor clinical trials in progress, and to validate their procedure by the use of a formal sequential design. An interactive program, written in FORTRAN 77 and called "PEST: Planning and Evaluation of Sequential Tests," is introduced. The program can be used to design trials based on the sequential probability ratio test, the triangular test, and the restricted procedure, among others. Furthermore, from the observed terminal values of the test statistics, the program will provide an analysis which includes the significance level and point and interval estimates of the parameter of interest. The computations are based on large-sample theory which encompasses many types of patient response, including binary and ordinal outcomes as well as survival times.
Authors:
J Whitehead; P Marek
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Computers and biomedical research, an international journal     Volume:  18     ISSN:  0010-4809     ISO Abbreviation:  Comput. Biomed. Res.     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-06-18     Completed Date:  1985-06-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0100331     Medline TA:  Comput Biomed Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  176-83     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Clinical Trials as Topic*
Computers*
Humans
Probability
Research Design / methods
Software*
Statistics as Topic
Grant Support
ID/Acronym/Agency:
GM-28314/GM/NIGMS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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