Document Detail

FLU, a negative feedback regulator of tetrapyrrole biosynthesis, is physically linked to the final steps of the Mg(++)-branch of this pathway.
MedLine Citation:
PMID:  22212719     Owner:  NLM     Status:  Publisher    
Regulation of tetrapyrrole biosynthesis in higher plants has been attributed to negative feedback control. Two effectors of feedback inhibition have been identified, heme and the FLU protein. Inhibition by heme implicates the Fe-branch via regulation of the initial step of tetrapyrrole synthesis. In the present work a FLU-containing chloroplast membrane complex was identified, that besides FLU comprises the four enzymes catalyzing the final steps of chlorophyll synthesis. The results support the notion that FLU links chlorophyll synthesis and the target of feedback control, glutamyl-tRNA reductase, thereby allowing also the Mg-branch to control the initial step of tetrapyrrole synthesis. STRUCTURED SUMMARY OF PROTEIN INTERACTIONS: FLU, CHL27, PORB, PORC and CHLPphysically interact by blue native page (View interaction) FLUphysically interacts with CHL27, PORB, PORC, CHLP and GluTR by anti tag co-immunoprecipitation (View interaction) FLUphysically interacts with CHL27 by anti bait co-immunoprecipitation (View Interaction: 1, 2) FLUphysically interacts with CHL27 by anti tag co-immunoprecipitation (View interaction) FLUphysically interacts with CHL27, PORB, PORC and CHLP by anti tag co-immunoprecipitation (View interaction).
Dominika Kauss; Sylvain Bischof; Sandro Steiner; Klaus Apel; Rasa Meskauskiene
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-30
Journal Detail:
Title:  FEBS letters     Volume:  -     ISSN:  1873-3468     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2012-1-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier B.V.
Department of Biology & Zurich-Basel Plant Science Center, ETH Zurich, Universitatstr. 2, CH-8092 Zurich, Switzerland.
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