Document Detail

FLO11 expression and lipid biosynthesis are required for air liquid biofilm formation in a Saccharomyces cerevisiae flor strain.
MedLine Citation:
PMID:  22805178     Owner:  NLM     Status:  Publisher    
Air-liquid biofilm formation is largely dependent on Flo11p and seems related to cell lipid content and composition. Here, it is shown that in the presence of cerulenin, a known inhibitor of the fatty acid synthase complex, biofilm formation is inhibited together with FLO11 transcription in a flor strain of Saccharomyces cerevisiae, while the administration of saturated fatty acids to cerulenin containing medium restores biofilm formation and FLO11 transcription. It is also shown that, in biofilm cells, the transcription FLO11 is accompanied by the transcription of ACC1, ACS1 and INO1, key genes in lipid biosynthesis and that biofilm formation is affected by lack of inositol in flor medium. These results are compatible with the hypothesis that air-liquid biofilm formation depends on FLO11 transcription levels as well as on fatty acids biosynthesis. © 2012 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.
Giacomo Zara; Paola Goffrini; Tiziana Lodi; Severino Zara; Ilaria Mannazzu; Marilena Budroni
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-16
Journal Detail:
Title:  FEMS yeast research     Volume:  -     ISSN:  1567-1364     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101085384     Medline TA:  FEMS Yeast Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.
Dipartimento di Agraria, Università di Sassari, v.le Italia, 39, 07100, Sassari, Italy.
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