Document Detail


FISH-negative cryptic PML-RARA rearrangement detected by long-distance polymerase chain reaction and sequencing analyses: a case study and review of the literature.
MedLine Citation:
PMID:  21156244     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although a normal karyotype according to conventional cytogenetic analysis in association with cryptic t(15;17) has been infrequently reported in cases of acute promyelocytic leukemia (APL), a fluorescence in situ hybridization (FISH)-negative cryptic PML-RARA rearrangement is even more rare, with only 12 such APL cases of FISH-negative cryptic PML-RARA rearrangements in the literature. Reported here is an additional clinical APL case with a FISH-negative cryptic PML-RARA rearrangement, confirmed by long-distance DNA polymerase chain reaction method. Discussion includes a relevant literature review of similar cases. DNA-PCR can be a useful tool for the analysis of complex and cryptic rearrangements.
Authors:
Min Jin Kim; Sun Young Cho; Myeong-Hee Kim; Jae Jin Lee; So Young Kang; Eun Hae Cho; Jungwon Huh; Hwi-Joong Yoon; Tae Sung Park; Woo-In Lee; Rolf Marschalek; Claus Meyer
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  203     ISSN:  1873-4456     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-15     Completed Date:  2011-01-04     Revised Date:  2012-10-30    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  278-83     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Affiliation:
Department of Laboratory Medicine, School of Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-702, Korea.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Chromosomes / ultrastructure
Cytogenetics*
Female
Gene Rearrangement*
Genome, Human
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Male
Middle Aged
Oncogene Proteins, Fusion / genetics*
Polymerase Chain Reaction / methods*
Reverse Transcriptase Polymerase Chain Reaction / methods
Sequence Analysis, DNA / methods*
Chemical
Reg. No./Substance:
0/Oncogene Proteins, Fusion; 0/promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein
Comments/Corrections
Comment In:
Ann Hematol. 2012 Oct;91(10):1645-8   [PMID:  22402611 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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