| FISH-negative cryptic PML-RARA rearrangement detected by long-distance polymerase chain reaction and sequencing analyses: a case study and review of the literature. | |
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MedLine Citation:
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PMID: 21156244 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although a normal karyotype according to conventional cytogenetic analysis in association with cryptic t(15;17) has been infrequently reported in cases of acute promyelocytic leukemia (APL), a fluorescence in situ hybridization (FISH)-negative cryptic PML-RARA rearrangement is even more rare, with only 12 such APL cases of FISH-negative cryptic PML-RARA rearrangements in the literature. Reported here is an additional clinical APL case with a FISH-negative cryptic PML-RARA rearrangement, confirmed by long-distance DNA polymerase chain reaction method. Discussion includes a relevant literature review of similar cases. DNA-PCR can be a useful tool for the analysis of complex and cryptic rearrangements. |
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Authors:
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Min Jin Kim; Sun Young Cho; Myeong-Hee Kim; Jae Jin Lee; So Young Kang; Eun Hae Cho; Jungwon Huh; Hwi-Joong Yoon; Tae Sung Park; Woo-In Lee; Rolf Marschalek; Claus Meyer |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Cancer genetics and cytogenetics Volume: 203 ISSN: 1873-4456 ISO Abbreviation: Cancer Genet. Cytogenet. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-15 Completed Date: 2011-01-04 Revised Date: 2012-10-30 |
Medline Journal Info:
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Nlm Unique ID: 7909240 Medline TA: Cancer Genet Cytogenet Country: United States |
Other Details:
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Languages: eng Pagination: 278-83 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Laboratory Medicine, School of Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-702, Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Chromosomes / ultrastructure Cytogenetics* Female Gene Rearrangement* Genome, Human Humans In Situ Hybridization, Fluorescence Karyotyping Male Middle Aged Oncogene Proteins, Fusion / genetics* Polymerase Chain Reaction / methods* Reverse Transcriptase Polymerase Chain Reaction / methods Sequence Analysis, DNA / methods* |
| Chemical | |
Reg. No./Substance:
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0/Oncogene Proteins, Fusion; 0/promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein |
| Comments/Corrections | |
Comment In:
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Ann Hematol. 2012 Oct;91(10):1645-8
[PMID:
22402611
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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