Document Detail

FISH-negative cryptic PML-RARA rearrangement detected by long-distance polymerase chain reaction and sequencing analyses: a case study and review of the literature.
MedLine Citation:
PMID:  21156244     Owner:  NLM     Status:  MEDLINE    
Although a normal karyotype according to conventional cytogenetic analysis in association with cryptic t(15;17) has been infrequently reported in cases of acute promyelocytic leukemia (APL), a fluorescence in situ hybridization (FISH)-negative cryptic PML-RARA rearrangement is even more rare, with only 12 such APL cases of FISH-negative cryptic PML-RARA rearrangements in the literature. Reported here is an additional clinical APL case with a FISH-negative cryptic PML-RARA rearrangement, confirmed by long-distance DNA polymerase chain reaction method. Discussion includes a relevant literature review of similar cases. DNA-PCR can be a useful tool for the analysis of complex and cryptic rearrangements.
Min Jin Kim; Sun Young Cho; Myeong-Hee Kim; Jae Jin Lee; So Young Kang; Eun Hae Cho; Jungwon Huh; Hwi-Joong Yoon; Tae Sung Park; Woo-In Lee; Rolf Marschalek; Claus Meyer
Related Documents :
532074 - Yersiniosis in a free-living fallow deer.
1593704 - Psoas abscess: case report and review of the literature.
6421554 - Perforated diverticulum of the terminal ileum. a previously unreported cause of suppura...
16410214 - Unilateral traumatic posterior fossa subdural effusion in an infant.
1261064 - Cardio-cutaneous syndrome (the "leopard" syndrome). review of the literature and a new ...
21152224 - Right colonic diverticulitis.
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  203     ISSN:  1873-4456     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-15     Completed Date:  2011-01-04     Revised Date:  2012-10-30    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  278-83     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Department of Laboratory Medicine, School of Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-702, Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Chromosomes / ultrastructure
Gene Rearrangement*
Genome, Human
In Situ Hybridization, Fluorescence
Middle Aged
Oncogene Proteins, Fusion / genetics*
Polymerase Chain Reaction / methods*
Reverse Transcriptase Polymerase Chain Reaction / methods
Sequence Analysis, DNA / methods*
Reg. No./Substance:
0/Oncogene Proteins, Fusion; 0/promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein
Comment In:
Ann Hematol. 2012 Oct;91(10):1645-8   [PMID:  22402611 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Correlation between clinical characteristics, survival and genetic alterations in patients with hepa...
Next Document:  B lymphoblastic leukemia with ETV6 amplification.