Document Detail

FIP1L1-PDGFRA and c-kit D816V mutation-based clonality studies in systemic mast cell disease associated with eosinophilia.
MedLine Citation:
PMID:  15257945     Owner:  NLM     Status:  MEDLINE    
Laboratory methods to detect both FIP1L1-PDGFRA and c-kit D816V mutations were combined with immunomagnetic cell separation to study the extent of clonal involvement by both myeloid and lymphoid cells in 3 patients with systemic mastocytosis associated with eosinophilia. The results suggested an early stem cell origin for the FIP1L1-PDGFRA mutation.
Ayalew Tefferi; Terra L Lasho; Stephanie R Brockman; Michelle A Elliott; Angela Dispenzieri; Animesh Pardanani
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Publication Detail:
Type:  Letter; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Haematologica     Volume:  89     ISSN:  1592-8721     ISO Abbreviation:  Haematologica     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-07-19     Completed Date:  2006-05-17     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0417435     Medline TA:  Haematologica     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  871-3     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Eosinophilia / complications,  genetics
Mastocytosis, Systemic / blood,  complications,  genetics*
Middle Aged
Oncogene Proteins, Fusion / genetics*
Proto-Oncogene Proteins c-kit / genetics*
Receptor, Platelet-Derived Growth Factor alpha / genetics*
mRNA Cleavage and Polyadenylation Factors / genetics*
Reg. No./Substance:
0/FIP1L1-PDGFRA fusion protein, human; 0/Oncogene Proteins, Fusion; 0/mRNA Cleavage and Polyadenylation Factors; EC Proteins c-kit; EC, Platelet-Derived Growth Factor alpha

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