Document Detail

FIP1L1-PDGFRA and c-kit D816V mutation-based clonality studies in systemic mast cell disease associated with eosinophilia.
MedLine Citation:
PMID:  15257945     Owner:  NLM     Status:  MEDLINE    
Laboratory methods to detect both FIP1L1-PDGFRA and c-kit D816V mutations were combined with immunomagnetic cell separation to study the extent of clonal involvement by both myeloid and lymphoid cells in 3 patients with systemic mastocytosis associated with eosinophilia. The results suggested an early stem cell origin for the FIP1L1-PDGFRA mutation.
Ayalew Tefferi; Terra L Lasho; Stephanie R Brockman; Michelle A Elliott; Angela Dispenzieri; Animesh Pardanani
Related Documents :
11289205 - A one-tube nested polymerase chain reaction for the detection of mycobacterium bovis in...
2758585 - Determination of magnesium in granulocytes.
7812985 - Cell type identification in leukemia: the level of agreement among four independent dia...
15051035 - The effect of the elapsed time between blood draw and processing on the recovery of fet...
15239955 - The pdgf/vegf receptor controls blood cell survival in drosophila.
22887595 - Poloxamer synperonic f108 improves cellular transduction with lentiviral vectors.
Publication Detail:
Type:  Letter; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Haematologica     Volume:  89     ISSN:  1592-8721     ISO Abbreviation:  Haematologica     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-07-19     Completed Date:  2006-05-17     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0417435     Medline TA:  Haematologica     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  871-3     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Eosinophilia / complications,  genetics
Mastocytosis, Systemic / blood,  complications,  genetics*
Middle Aged
Oncogene Proteins, Fusion / genetics*
Proto-Oncogene Proteins c-kit / genetics*
Receptor, Platelet-Derived Growth Factor alpha / genetics*
mRNA Cleavage and Polyadenylation Factors / genetics*
Reg. No./Substance:
0/FIP1L1-PDGFRA fusion protein, human; 0/Oncogene Proteins, Fusion; 0/mRNA Cleavage and Polyadenylation Factors; EC Proteins c-kit; EC, Platelet-Derived Growth Factor alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Polyethylene glycol interferon-alpha2b alone or in combination with low-dose Ara-C in patients newly...
Next Document:  Detection of bcl-2 rearrangement in mucosa-associated lymphoid tissue lymphomas from patients with h...