Document Detail


FGFs and metabolism.
MedLine Citation:
PMID:  19683963     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although the first fibroblast growth factor (FGF) was discovered as a mitogen on 3T3 fibroblasts [Gospodarowicz D: Localization of a fibroblast growth factor and its effect alone and with hydrocortisone on 3T3 cell growth. Nature 1974, 249:123-127], this name is functionally misleading. This group of secreted proteins consisting now of 22 members was composed based on common structural characteristics rather than on functional similarity. Thus, only a few members of the human FGF family promote growth and strictly act on fibroblasts. While the research in the last century firmly established FGFs as key players in development, morphogenesis, angiogenesis, hematopoiesis, and survival, this decade provided clues on FGF roles in metabolism. In particular, 'hormone-like' FGF19, FGF21, and FGF23, were shown to be involved in glucose, lipid, bile acid, phosphate, and vitamin D metabolism but the mechanisms underlying their functions as metabolic regulators are still being defined.
Authors:
Alexei Kharitonenkov
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-08-14
Journal Detail:
Title:  Current opinion in pharmacology     Volume:  9     ISSN:  1471-4973     ISO Abbreviation:  Curr Opin Pharmacol     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-25     Completed Date:  2010-02-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100966133     Medline TA:  Curr Opin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  805-10     Citation Subset:  IM    
Affiliation:
Eli Lilly and Company, Lilly Research Laboratories, BioTechnology Discovery Research, Lilly Corporate Center, Indianapolis, IN 46285, USA. a.kharch@lilly.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Drug Delivery Systems
Fibroblast Growth Factors / physiology*,  therapeutic use
Humans
Metabolic Diseases / drug therapy
Metabolism / physiology*
Chemical
Reg. No./Substance:
0/FGF19 protein, human; 0/fibroblast growth factor 21; 0/fibroblast growth factor 23; 62031-54-3/Fibroblast Growth Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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