Document Detail

FGFR2 genotype and risk of radiation-associated breast cancer in Hodgkin lymphoma.
MedLine Citation:
PMID:  22144180     Owner:  NLM     Status:  MEDLINE    
Women treated at young ages with supradiaphragmatic radiotherapy for Hodgkin lymphoma (HL) have a highly increased risk of breast cancer. For personalized advice and follow-up regimens for patients, information is needed on how the radiotherapy-related risk is affected by other breast cancer risk factors. Genome-wide association studies have identified 14 independently replicated common single nucleotide polymorphisms that influence breast cancer risk. To examine whether these variants contribute to risk of radiation-associated breast cancer in HL, we analyzed 2 independent case-control series, from the United Kingdom and The Netherlands, totaling 693 HL patients, 232 with breast cancer and 461 without. rs1219648, which annotates the FGFR2 gene, was associated with risk in both series (combined per-allele odds ratio = 1.59, 95% confidence interval: 1.26-2.02; P = .000111). These data provide evidence that genetic variation in FGFR2 influences radiation-induced breast cancer risk.
Yussanne P Ma; Flora E van Leeuwen; Rosie Cooke; Annegien Broeks; Victor Enciso-Mora; Bianca Olver; Amy Lloyd; Peter Broderick; Nicola S Russell; Cecile Janus; Alan Ashworth; Richard S Houlston; Anthony J Swerdlow
Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't     Date:  2011-12-05
Journal Detail:
Title:  Blood     Volume:  119     ISSN:  1528-0020     ISO Abbreviation:  Blood     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-27     Completed Date:  2012-03-13     Revised Date:  2012-06-05    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1029-31     Citation Subset:  AIM; IM    
Section of Cancer Genetics, Institute of Cancer Research, 15 Cotswold Rd., Sutton, Surrey, United Kingdom.
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MeSH Terms
Age Factors
Breast Neoplasms / complications,  etiology,  genetics*
Case-Control Studies
Genetic Predisposition to Disease
Great Britain / epidemiology
Hodgkin Disease / complications,  genetics,  radiotherapy*
Individualized Medicine
Mammary Glands, Human / radiation effects*
Middle Aged
Netherlands / epidemiology
Polymorphism, Single Nucleotide*
Receptor, Fibroblast Growth Factor, Type 2 / genetics*
Grant Support
//Cancer Research UK
Reg. No./Substance:
EC protein, human; EC, Fibroblast Growth Factor, Type 2

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