| FGF9: a motoneuron survival factor expressed by medial thoracic and sacral motoneurons. | |
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MedLine Citation:
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PMID: 10723063 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the nervous system, fibroblast growth factor-9 (FGF9) is produced mainly by neurons. By whole-mount in situ hybridization, on embryonic rat spinal cord, we observed Fgf9 expression in a subpopulation of motoneurons located in the thoracic and sacral regions of the median motor column that innervate the axial muscles. Furthermore, FGF9 prevented death of purified rat and chicken motoneurons in culture in the same concentration range as FGF2. The targets of FGF9 are more restricted than that of the other FGFs, however, because conversely to FGF1 or FGF2, FGF9 had only weak or inexistent survival effects on chicken ciliary neurons or rat DRG. FGF9 may therefore play a role as an autocrine/paracrine survival factor for motoneurons. |
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Authors:
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A Garcès; H Nishimune; J M Philippe; B Pettmann; O deLapeyrière |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neuroscience research Volume: 60 ISSN: 0360-4012 ISO Abbreviation: J. Neurosci. Res. Publication Date: 2000 Apr |
Date Detail:
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Created Date: 2000-04-12 Completed Date: 2000-04-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600111 Medline TA: J Neurosci Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1-9 Citation Subset: IM |
Copyright Information:
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Copyright 2000 Wiley-Liss, Inc. |
Affiliation:
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INSERM U.382, Institut de Biologie du Développement de Marseille (INSERM-CNRS-Univ. Méditerraneé-AP Marseille), Campus de Luminy, Marseille, France. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cells, Cultured Chick Embryo Fibroblast Growth Factor 9 Fibroblast Growth Factors* Ganglia, Parasympathetic / cytology, embryology, metabolism Ganglia, Spinal / cytology, embryology, metabolism Growth Substances / metabolism* Motor Neurons / metabolism* Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction Sacrococcygeal Region Spinal Cord / cytology, embryology, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Fgf9 protein, rat; 0/Fibroblast Growth Factor 9; 0/Growth Substances; 62031-54-3/Fibroblast Growth Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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