| FGF23 is a putative marker for bone healing and regeneration. | |
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MedLine Citation:
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PMID: 19215029 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Besides numerous other factors, fibroblast growth factor receptor (FGFR) signaling is involved in fracture healing and bone remodeling. FGF23 is a phosphatonin produced by osteoblastic cells, which signals via FGFR1, thereby exerting effects in bone and kidney. We analyzed if serum FGF23 levels might be an indicator to predict fracture healing and union. FGF23 (C-Term) was elevated on day 3 postoperatively in 55 patients sustaining an exchange of total hip implants due to aseptic loosening. A prospective study of 40 patients undergoing primary hip arthroplasty also showed elevated FGF23 (C-Term) but no change in FGF23 (intact) levels on days 1, 4, and 10 postoperatively. Serum phosphate and phosphate clearance stayed within normal ranges. FGF23 mRNA expression in ovine callus was compared between a standard and delayed course of osteotomy healing. In the standard model, a marked increase in FGF23 mRNA expression compared to the delayed healing situation was observed. Immunohistochemical analysis showed FGF23 production of osteoblasts and granulation tissue in the fracture callus during bone healing. In conclusion, FGF23 is involved in bone healing, can be measured by a sensitive assay in peripheral blood, and is a promising candidate as an indicator for healing processes prone to reunion versus nonunion. |
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Authors:
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Sascha Goebel; Jasmin Lienau; Ulrich Rammoser; Lothar Seefried; Karl Florian Wintgens; Jochen Seufert; Georg Duda; Franz Jakob; Regina Ebert |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of orthopaedic research : official publication of the Orthopaedic Research Society Volume: 27 ISSN: 1554-527X ISO Abbreviation: J. Orthop. Res. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-11 Completed Date: 2009-09-01 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 8404726 Medline TA: J Orthop Res Country: United States |
Other Details:
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Languages: eng Pagination: 1141-6 Citation Subset: IM |
Copyright Information:
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(c) 2009 Orthopaedic Research Society. |
Affiliation:
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Orthopedic Center for Musculoskeletal Research, University of Wuerzburg, Wuerzburg, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alkaline Phosphatase
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blood Animals Arthroplasty, Replacement, Hip / adverse effects Biological Markers / blood* Bony Callus / physiology Enzyme-Linked Immunosorbent Assay Female Fibroblast Growth Factors / blood*, genetics* Fracture Healing / physiology* Humans Male Middle Aged Osteoblasts / physiology Osteotomy Phosphates / blood Pilot Projects Predictive Value of Tests Prospective Studies Prosthesis Failure RNA, Messenger / metabolism Regeneration / physiology* Sheep |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Phosphates; 0/RNA, Messenger; 0/fibroblast growth factor 23; 62031-54-3/Fibroblast Growth Factors; EC 3.1.3.1/Alkaline Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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