Document Detail

FGF10 is required for cell proliferation and gland formation in the stomach epithelium of the chicken embryo.
MedLine Citation:
PMID:  16616737     Owner:  NLM     Status:  MEDLINE    
The development of digestive organs in vertebrates involves active epithelial-mesenchymal interactions. In the chicken proventriculus (glandular stomach), the morphogenesis and cytodifferentiation of the epithelium are controlled by the inductive signaling factors that are secreted from the underlying mesenchyme. Previous studies have shown that Fgf10 is expressed in the developing chicken proventricular mesenchyme, whereas its receptors are present in the epithelium. In our present study, we show that FGF10 is an early mesenchymal signal that is critically associated with the developmental processes in the proventricular epithelium. Furthermore, virus-mediated Fgf10 overexpression in ovo results in a hypermorphic epithelial structure and an increase in epithelial cell number. In contrast, the overexpression of a secreted FGFR2b (sFGFR2b), an FGF10 antagonist, blocks cell proliferation and gland formation in the proventricular epithelium in ovo. This downregulation of proliferative activity was subsequently found to retard gland formation and also to delay differentiation of the epithelium. These results demonstrate that FGF10 signaling, mediated by FGFR1b and/or FGFR2b, is required for proliferation and gland formation in the epithelium in the developing chick embryo.
Masahiro Shin; Sumihare Noji; Annette Neubüser; Sadao Yasugi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-04-17
Journal Detail:
Title:  Developmental biology     Volume:  294     ISSN:  0012-1606     ISO Abbreviation:  Dev. Biol.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-15     Completed Date:  2006-07-13     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  11-23     Citation Subset:  IM    
Department of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, 1-1 Minamiohsawa, Hachioji, Tokyo 192-0397, Japan.
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MeSH Terms
Cell Proliferation
Chick Embryo
Epithelium / embryology,  growth & development*
Fibroblast Growth Factor 10 / antagonists & inhibitors,  physiology*
Gastric Mucosa / embryology,  growth & development*
Receptor, Fibroblast Growth Factor, Type 2 / physiology
Signal Transduction
Stomach / cytology,  embryology,  growth & development*
Reg. No./Substance:
0/Fibroblast Growth Factor 10; EC, Fibroblast Growth Factor, Type 2

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