Document Detail

FGF signaling is essential for ophthalmic trigeminal placode cell delamination and differentiation.
MedLine Citation:
PMID:  19347953     Owner:  NLM     Status:  MEDLINE    
The ophthalmic trigeminal (opV) placode gives rise exclusively to sensory neurons of the peripheral nervous system, providing an advantageous model for understanding neurogenesis. The signaling pathways governing opV placode development have only recently begun to be elucidated. Here, we investigate the fibroblast growth factor receptor-4 (FGFR4), an opV expressed gene, to examine if and how FGF signaling regulates opV placode development. After inhibiting FGFR4, Pax3+ opV placode cells failed to delaminate from the ectoderm and did not contribute to the opV ganglion. Blocking FGF signaling also led to a loss of the early and late neuronal differentiation markers Ngn2, Islet-1, NeuN, and Neurofilament. In addition, without FGF signaling, cells that stalled in the ectoderm lost their opV placode-specific identity by down-regulating Pax3. We conclude that FGF signaling, through FGFR4, is necessary for delamination and differentiation of opV placode cells.
Rhonda N T Lassiter; Stephanie B Reynolds; Kristopher D Marin; Tyler F Mayo; Michael R Stark
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental dynamics : an official publication of the American Association of Anatomists     Volume:  238     ISSN:  1058-8388     ISO Abbreviation:  Dev. Dyn.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-30     Completed Date:  2009-07-28     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  9201927     Medline TA:  Dev Dyn     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1073-82     Citation Subset:  IM    
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MeSH Terms
Chick Embryo
Fibroblast Growth Factors / metabolism*
Homeodomain Proteins / metabolism
LIM-Homeodomain Proteins
Nerve Tissue Proteins / metabolism
Neurofilament Proteins / metabolism*
Neurogenesis* / genetics
Ophthalmic Nerve / cytology,  embryology*,  metabolism
Paired Box Transcription Factors / metabolism
Receptor, Fibroblast Growth Factor, Type 4 / genetics,  metabolism*
Sensory Receptor Cells / metabolism,  physiology*
Signal Transduction / physiology
Transcription Factors
Grant Support
1R01HD046475-01/HD/NICHD NIH HHS; 5R03HD041470-02/HD/NICHD NIH HHS; R01 HD046475/HD/NICHD NIH HHS; R01 HD046475-01A2/HD/NICHD NIH HHS; R01 HD046475-02/HD/NICHD NIH HHS; R01 HD046475-03/HD/NICHD NIH HHS; R01 HD046475-04/HD/NICHD NIH HHS; R01 HD046475-05/HD/NICHD NIH HHS
Reg. No./Substance:
0/Homeodomain Proteins; 0/LIM-Homeodomain Proteins; 0/Nerve Tissue Proteins; 0/Neurofilament Proteins; 0/Paired Box Transcription Factors; 0/Transcription Factors; 0/insulin gene enhancer binding protein Isl-1; 62031-54-3/Fibroblast Growth Factors; EC, Fibroblast Growth Factor, Type 4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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