Document Detail


FGF-R3 and OPG expression in patient with multiple myeloma following systemic sclerosis: case report and review of the literature.
MedLine Citation:
PMID:  21207214     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The presence of multiple myeloma (MM) in a patient with systemic sclerosis is a rare and unusual occurrence with unclear significance. We report the case of a 55-year-old woman with a 20-year history of systemic sclerosis, who subsequently presented with clinical stage IIIA IgG-λ MM. The systemic sclerosis was diagnosed and treated in 1988 with D: -penicillamine and methotrexate. Twenty years later, in December 2008, she presented with symptoms of Raynaud's phenomenon and intense facial pruritus. Immunoelectrophoresis confirmed the presence of a IgG-λ paraprotein (71.90 g/l) and Bence Jones proteinuria of the lambda light chains. Bone marrow histology revealed infiltrates of plasmocytes and lymphoplasmocytes which were on immunohistochemistry CD38+, FGF-R3+ and OPG+. An extensive X-ray skeletal survey did not show any osteolytic lesions or fractures. The patient was treated according to the CTD protocol (cyclophosphamide, thalidomide, and dexamethasone) which was effective against the myeloma as well as the systemic sclerosis and patient achieved complete remission.
Authors:
Milica Čolović; Vladimir Jurisic; Jelena Bila; Natasa Čolović; Vuk Palibrk
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-01-05
Journal Detail:
Title:  International journal of hematology     Volume:  93     ISSN:  1865-3774     ISO Abbreviation:  Int. J. Hematol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-17     Completed Date:  2011-06-09     Revised Date:  2012-06-05    
Medline Journal Info:
Nlm Unique ID:  9111627     Medline TA:  Int J Hematol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  228-31     Citation Subset:  IM    
Affiliation:
Institute of Hematology, Clinical Center of Serbia, Koste Todorovića 2, Belgrade, Serbia.
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MeSH Terms
Descriptor/Qualifier:
Bone Marrow / metabolism,  pathology
Female
Humans
Middle Aged
Multiple Myeloma / complications*,  metabolism*,  pathology
Osteoprotegerin / metabolism*
Receptor, Fibroblast Growth Factor, Type 3 / metabolism*
Scleroderma, Systemic / complications*
Chemical
Reg. No./Substance:
0/Osteoprotegerin; 0/TNFRSF11B protein, human; EC 2.7.10.1/FGFR3 protein, human; EC 2.7.10.1/Receptor, Fibroblast Growth Factor, Type 3

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