Document Detail


FGF-23 and vitamin D: don't shoot the messenger?
MedLine Citation:
PMID:  22523113     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The discovery of fibroblast growth factor-23 (FGF-23) as a key regulator of phosphate and vitamin D metabolism has forced a rethink about the mineral and bone disorder of chronic kidney disease (CKD). FGF-23 powerfully predicts adverse cardiovascular outcomes in patients with CKD and an important question is whether treatment regimens should now be tailored to address FGF-23 levels in addition to those of calcium, phosphate, parathyroid hormone and vitamin D. Nevertheless, despite the known action of active vitamin D therapies to increase FGF-23, this should probably still form an important part of the management of patients with hyperparathyroidism and perhaps at low doses of essentially all patients with advanced renal disease.
Authors:
Richard S Fish; John Cunningham
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Publication Detail:
Type:  Comment; Editorial     Date:  2012-04-20
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  27     ISSN:  1460-2385     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-31     Completed Date:  2012-10-02     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  2137-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Bone Density Conservation Agents / therapeutic use*
Ergocalciferols / therapeutic use*
Female
Fibroblast Growth Factors / metabolism*
Humans
Hydroxycholecalciferols / therapeutic use*
Hyperparathyroidism, Secondary / drug therapy*,  metabolism*
Male
Chemical
Reg. No./Substance:
0/Bone Density Conservation Agents; 0/Ergocalciferols; 0/Hydroxycholecalciferols; 0/fibroblast growth factor 23; 131918-61-1/paricalcitol; 62031-54-3/Fibroblast Growth Factors; URQ2517572/alfacalcidol
Comments/Corrections
Comment On:
Nephrol Dial Transplant. 2012 Jun;27(6):2263-9   [PMID:  22140123 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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