| FGF-2 stimulates migration of Kaposi's sarcoma-like vascular cells by HGF-dependent relocalization of the urokinase receptor. | |
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MedLine Citation:
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PMID: 9707175 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The spindle-shaped cell line TTB was recently isolated from highly vascularized skin lesions of BKV/HIV-1 tat transgenic mice and shown to possess an autocrine loop for hepatocyte growth factor (HGF). We show that fibroblast growth factor-2 (FGF-2) stimulates TTB cell migration and promotes polarization of uPAR at the leading edge of migrating cells. FGF-stimulated TTB cells presented the typical migratory phenotype, with a triangular cell shape and concomitant breakdown of actin stress fibers and smooth muscle-specific actin isoform. FGF-2-stimulated migration was blocked by antibodies against urokinase-type plasminogen activator (uPA) or uPA receptor (uPAR) and by neutralizing anti-HGF antibodies. The latter also inhibited uPAR relocalization at the cell surface of FGF-2-treated TTB cells. This points to a crosstalk between FGF-2 and HGF that might mediate TTB cell migration by modulating the localization of cell surface uPAR. |
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Authors:
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U Cavallaro; Z Wu; A Di Palo; R Montesano; M S Pepper; J A Maier; M R Soria |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: FASEB journal : official publication of the Federation of American Societies for Experimental Biology Volume: 12 ISSN: 0892-6638 ISO Abbreviation: FASEB J. Publication Date: 1998 Aug |
Date Detail:
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Created Date: 1998-09-02 Completed Date: 1998-09-02 Revised Date: 2012-02-15 |
Medline Journal Info:
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Nlm Unique ID: 8804484 Medline TA: FASEB J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1027-34 Citation Subset: IM; X |
Affiliation:
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Department of Biological and Technological Research, San Raffaele Scientific Institute, Milano, Italy. cavallu@dibit.hsr.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Line Cell Movement* Cytoskeleton Fibroblast Growth Factor 2 / pharmacology* Hepatocyte Growth Factor / metabolism*, secretion Receptors, Cell Surface / metabolism* Receptors, Urokinase Plasminogen Activator Sarcoma, Kaposi Urokinase-Type Plasminogen Activator / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Plaur protein, mouse; 0/Receptors, Cell Surface; 0/Receptors, Urokinase Plasminogen Activator; 103107-01-3/Fibroblast Growth Factor 2; 67256-21-7/Hepatocyte Growth Factor; EC 3.4.21.73/Urokinase-Type Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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