| FGF-10 is decreased in bronchopulmonary dysplasia and suppressed by Toll-like receptor activation. | |
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MedLine Citation:
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PMID: 17071719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many extremely preterm infants continue to suffer from bronchopulmonary dysplasia, which results from abnormal saccular-stage lung development. Here, we show that fibroblast growth factor-10 (FGF-10) is required for saccular lung development and reduced in the lung tissue of infants with bronchopulmonary dysplasia. Although exposure to bacteria increases the risk of bronchopulmonary dysplasia, no molecular target has been identified connecting inflammatory stimuli and abnormal lung development. In an experimental mouse model of saccular lung development, activation of Toll-like receptor 2 (TLR2) or Toll-like receptor 4 (TLR4) inhibited FGF-10 expression, leading to abnormal saccular airway morphogenesis. In addition, Toll-mediated FGF-10 inhibition disrupted the normal positioning of myofibroblasts around saccular airways, similar to the mislocalization of myofibroblasts seen in patients with bronchopulmonary dysplasia. Reduced FGF-10 expression may therefore link the innate immune system and impaired lung development in bronchopulmonary dysplasia. |
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Authors:
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John T Benjamin; Rebekah J Smith; Brian A Halloran; Timothy J Day; David R Kelly; Lawrence S Prince |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-10-27 |
Journal Detail:
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Title: American journal of physiology. Lung cellular and molecular physiology Volume: 292 ISSN: 1040-0605 ISO Abbreviation: Am. J. Physiol. Lung Cell Mol. Physiol. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-02-09 Completed Date: 2007-03-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901229 Medline TA: Am J Physiol Lung Cell Mol Physiol Country: United States |
Other Details:
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Languages: eng Pagination: L550-8 Citation Subset: IM |
Affiliation:
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Departments of Pediatrics, Children's Hospital of Alabama, University of Alabama at Birmingham, Birmingham, AL 35294, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bronchopulmonary Dysplasia / immunology, metabolism*, pathology Disease Models, Animal* Female Fetus / drug effects, pathology Fibroblast Growth Factor 10 / genetics, metabolism* Fibroblasts / drug effects, pathology Gene Expression Regulation / drug effects Humans Infant, Newborn Lipopolysaccharides / pharmacology Lung / drug effects, pathology Mice Mice, Inbred BALB C RNA, Messenger / genetics, metabolism Toll-Like Receptor 2 / metabolism* Toll-Like Receptor 4 / metabolism* Transforming Growth Factor beta / metabolism |
| Chemical | |
Reg. No./Substance:
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0/FGF10 protein, human; 0/Fgf10 protein, mouse; 0/Fibroblast Growth Factor 10; 0/Lipopolysaccharides; 0/RNA, Messenger; 0/Toll-Like Receptor 2; 0/Toll-Like Receptor 4; 0/Transforming Growth Factor beta |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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