Document Detail


The FEMA GRAS assessment of furfural used as a flavour ingredient. Flavor and Extract Manufacturers' Association.
MedLine Citation:
PMID:  9350219     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Expert Panel of the Flavor and Extract Manufacturers' Association (FEMA) has assessed the safety of furfural for its continued use as a flavour ingredient. The safety assessment takes into account the current scientific information on exposure, metabolism, pharmacokinetics, toxicology, carcinogenicity and genotoxicity. Furfural was reaffirmed as GRAS (GRASr) as a flavour ingredient under conditions of intended use based on: (1) its mode of metabolic detoxication in humans; (2) its low level of flavour use compared with higher intake levels as a naturally occurring component of food; (3) the safety factor calculated from results of subchronic and chronic studies, (4) the lack of reactivity with DNA; and (5) the conclusion that the only statistically significant finding in the 2-year NTP bioassays, an increased incidence of hepatocellular adenomas and carcinomas in the high-dose group of male mice, was secondary to pronounced hepatotoxicity. Taken together, these data do not indicate any risk to human health under conditions of use as a flavour ingredient. This evidence of safety is supported by the occurrence of furfural as a natural component of traditional foods, at concentrations in the diet resulting in a 'natural intake' that is at least 100 times higher than the intake of furfural from use as a flavour ingredient.
Authors:
T B Adams; J Doull; J I Goodman; I C Munro; P Newberne; P S Portoghese; R L Smith; B M Wagner; C S Weil; L A Woods; R A Ford
Related Documents :
23973839 - Characterization of aerobic spore-forming bacteria associated with industrial dairy pro...
8295039 - An anesthesia mask gas-scavenging system.
17719159 - Comparative safety testing of genetically modified foods in a 90-day rat feeding study ...
24674439 - Postharvest strategies for deoxynivalenol and zearalenone reduction in stored adlay (co...
18293609 - Evolution of the cooperation between the world organisation for animal health (oie) and...
12031059 - Safety pharmacology in the nonclinical assessment of new medicinal products: definition...
22466019 - 4-nonylphenol and bisphenol a in swedish food and exposure in swedish nursing women.
7302579 - The world food situation and global grain prospects.
14633009 - Nucleic acid sequence based amplification for the rapid and sensitive detection of salm...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  35     ISSN:  0278-6915     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-11-19     Completed Date:  1997-11-19     Revised Date:  2006-03-13    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  739-51     Citation Subset:  IM    
Affiliation:
Flavor and Extract Manufacturers' Association, Washington, DC 20006, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenoma, Liver Cell / chemically induced,  pathology
Animals
Carcinogenicity Tests
Carcinoma, Hepatocellular / chemically induced,  pathology
Drug Evaluation
Female
Flavoring Agents* / chemistry,  pharmacokinetics,  toxicity
Food Additives / standards*
Furaldehyde* / chemistry,  pharmacokinetics,  toxicity
Humans
Liver Neoplasms / chemically induced,  pathology
Male
Mice
Mutagenicity Tests
Rats
Safety
Chemical
Reg. No./Substance:
0/Flavoring Agents; 0/Food Additives; 98-01-1/Furaldehyde

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Ki-67 expression in relation to clinicopathological variables and prognosis in colorectal adenocarci...
Next Document:  Hepatic and associated response of rats to pregnancy, lactation and simultaneous treatment with buty...