Document Detail

FEF75 in asthma management.
MedLine Citation:
PMID:  18386434     Owner:  NLM     Status:  MEDLINE    
RATIONALE: Diagnosis of asthma is based on the presence of symptoms (clinical diagnosis) supported by lung function measurements, such as forced expiratory volume in one second (FEV1) and peak expiratory flow (PEF) variability. Recently, it has been reported that the forced expiratory flow at 25-75 of the pulmonary volume might be considered as a possible marker of early bronchial impairment in patients with allergic rhinitis. OBJECTIVES: The aim of this retrospective study was to identify the most reliable spirometric parameter for the follow up of intermittent allergic asthma. METHODS: Data from 108 outpatients with intermittent allergic asthma was studied. The spirometric parameters before and after 1 week of short aerosol therapy were analyzed. Patients were divided into three groups according to basal FEV1 values: those with all spirometric values normal, those with reduced FEV1 and those with normal FEV1 but reduced FEF75. RESULTS: There was a good correlation between the spirometric parameters analysed. FEF75 showed a greater significant reduction than FEV1 and PEF. Moreover, 26 of 38 patients with normal FEV1 (68 %) showed a reduction in FEF75. No significant differences were observed between FEV1 and PEF. After short aerosol therapy, FEV1 improved in 93% of patients, but many (61%) still had a reduced FEF75 value, thus the correlation between the two parameters decreased (from r= 0.68 to r = 0.40). CONCLUSIONS: On the basis of these observations, FEF75 should be reconsidered a usefull spirometric parameter for allergic asthma follow up.
Di Berardino Luigi; Della Torre Emanuel; Di Berardino Federica; Della Torre Fabrizio
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European annals of allergy and clinical immunology     Volume:  39     ISSN:  1764-1489     ISO Abbreviation:  Eur Ann Allergy Clin Immunol     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-04-04     Completed Date:  2008-07-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101466614     Medline TA:  Eur Ann Allergy Clin Immunol     Country:  France    
Other Details:
Languages:  eng     Pagination:  333-6     Citation Subset:  IM    
Paediatric Allergist, G.P. ASL Milan, Italy.
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MeSH Terms
Adrenal Cortex Hormones / therapeutic use
Adrenergic beta-Agonists / therapeutic use
Albuterol / therapeutic use
Anti-Asthmatic Agents / therapeutic use
Asthma / diagnosis,  drug therapy,  physiopathology*
Child, Preschool
Forced Expiratory Flow Rates*
Forced Expiratory Volume
Maximal Midexpiratory Flow Rate
Peak Expiratory Flow Rate
Retrospective Studies
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Adrenergic beta-Agonists; 0/Anti-Asthmatic Agents; 18559-94-9/Albuterol

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