Document Detail


FDG uptake in primary squamous cell carcinoma of the head and neck. The relationship between overexpression of glucose transporters and hexokinases, tumour proliferation and apoptosis.
MedLine Citation:
PMID:  21052609     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Aim: This study aimed at assessing the relationship between over-expression of glucose transporters and hexokinases, tumour proliferation and apoptosis corrected for cellularity and partial volume corrected (pvc) FDG SUV values in primary squamous cell carcinoma of the head and neck (pSCCHN). Patients, methods: In 27 consecutive patients suffering from pSCCHN, FDG SUVmax and mean pvc values of the primary tumour were derived from a pre-surgical routine staging FDG PET/CT examination. GLUT-1, GLUT-3, HK-1, HK-3 expression, tumour proliferation (Ki-67 staining) and the number of apoptotic cells (cleaved caspase-3 staining), corrected for tumour cellularity, were subsequently assessed on the corresponding post-surgically obtained biopsies and tumour specimens. FDG SUVmax and mean pvc values of pSCCHN were correlated with the corresponding histological findings. Results: FDG SUV max and mean pvc values correlated significantly: with GLUT-1 scores r = 0.408 (p = 0.04) and r = 0.439 (p = 0.03) as well as with the number of apoptotic cells r = 0.529 (p = 0.008) and r = 0.484 (p = 0.017). The number of apoptotic cells also correlated to GLUT-3 scores: r = 0.62 (p = 0.001) and GLUT-1 scores r = 0.528 (p = 0.008). Conclusion: FDG SUV pvc proved significantly related to GLUT-1 expression by tumour cells and to the absolute number of apoptotic cells. The latter finding warrants further exploration and confirmation by additional studies.
Authors:
P Deron; C Vangestel; I Goethals; A De Potter; M Peeters; H Vermeersch; C Van de Wiele
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Publication Detail:
Type:  Journal Article     Date:  2010-11-05
Journal Detail:
Title:  Nuklearmedizin. Nuclear medicine     Volume:  50     ISSN:  0029-5566     ISO Abbreviation:  Nuklearmedizin     Publication Date:  2011  
Date Detail:
Created Date:  2011-02-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7609387     Medline TA:  Nuklearmedizin     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  15-21     Citation Subset:  IM    
Affiliation:
Philippe Deron, M. D., Ghent University Hospital, Department of Head and Neck Surgery, De Pintelaan 185, 9000-B Gent, Belgium, Tel. +32/93 32 39 90, Fax +32/93 32 39 35, E-mail: Philippe.Deron@ugent.be.
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