| FDG-PET/CT in restaging of patients with recurrent breast cancer: possible impact on staging and therapy. | |
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MedLine Citation:
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PMID: 17537758 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We aimed to compare the value of combined positron emission tomography (PET)/CT, PET+CT (viewed side by side), CT alone and PET alone concerning the rTNM stage and influence on therapy in patients with recurrent breast cancer. 44 patients with suspicion of recurrent breast cancer underwent whole-body [18F]-2-fluoro-2-deoxy-d-glucose (FDG)-PET/CT. Images of combined PET/CT, PET+CT, PET alone and CT alone were evaluated by four blinded reader teams. Diagnostic accuracies and influence on therapy were compared. Histology and a mean clinical follow up of 456 days served as the standard of reference. Differences between the staging procedures were tested for statistical significance by McNemar's test. Overall TNM tumour stage was correctly determined in 40/44 patients with PET/CT, in 38/44 with PET+CT, in 36/44 with PET alone and in 36/44 patients with CT alone. No statistically significant difference was detected between all tested imaging modalities. PET/CT changed the therapy in two patients compared with PET+CT, in four patients compared with PET alone and in five patients compared with CT alone. Combined PET/CT appeared to be more accurate in assessing the rTNM and showed a moderate impact on therapy over PET and CT. Minor improvements were noted when compared with PET+CT. Experienced readers might therefore be able to provide accurate staging results for further therapy from separately acquired studies. |
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Authors:
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P Veit-Haibach; G Antoch; T Beyer; H Stergar; R Schleucher; E A M Hauth; A Bockisch |
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Publication Detail:
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Type: Evaluation Studies; Journal Article Date: 2007-05-30 |
Journal Detail:
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Title: The British journal of radiology Volume: 80 ISSN: 1748-880X ISO Abbreviation: Br J Radiol Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-08-20 Completed Date: 2007-09-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0373125 Medline TA: Br J Radiol Country: England |
Other Details:
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Languages: eng Pagination: 508-15 Citation Subset: AIM; IM |
Affiliation:
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Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany. patrick.veit@uni-essen.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Breast Neoplasms / pathology*, radiography, radionuclide imaging Colorectal Neoplasms / radiography, radionuclide imaging, secondary Female Fluorodeoxyglucose F18 / diagnostic use Humans Middle Aged Neoplasm Recurrence, Local / pathology, radiography, radionuclide imaging Neoplasm Staging Positron-Emission Tomography / methods* Radiopharmaceuticals / diagnostic use Sensitivity and Specificity Stomach Neoplasms / radiography, radionuclide imaging, secondary Tomography, X-Ray Computed / methods* |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
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