| FDG-PET/CT imaging for staging and target volume delineation in preoperative conformal radiotherapy of rectal cancer. | |
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MedLine Citation:
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PMID: 17931795 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate the potential impact of using (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) on staging and target volume delineation for patients affected by rectal cancer and candidates for preoperative conformal radiotherapy. METHODS AND MATERIALS: Twenty-five patients diagnosed with rectal cancer T3-4 N0-1 M0-1 and candidates for preoperative radiotherapy underwent PET/CT simulation after injection of 5.18 MBq/kg of FDG. Clinical stage was reassessed on the basis of FDG-PET/CT findings. The gross tumor volume (GTV) and the clinical target volume (CTV) were delineated first on CT and then on PET/CT images. The PET/CT-GTV and PET/CT-CTV were analyzed and compared with CT-GTV and CT-CTV, respectively. RESULTS: In 4 of 25 cases (24%), PET/CT affected tumor staging or the treatment purpose. In 3 of 25 cases (12%) staged N0 M0, PET/CT showed FDG uptake in regional lymph nodes and in a case also in the liver. In a patient with a single liver metastasis PET/CT detected multiple lesions, changing the treatment intent from curative to palliative. The PET/CT-GTV and PET/CT-CTV were significantly greater than the CT-GTV (p = 0.00013) and CT-CTV (p = 0.00002), respectively. The mean difference between PET/CT-GTV and CT-GTV was 25.4% and between PET/CT-CTV and CT-CTV was 4.1%. CONCLUSIONS: Imaging with PET/CT for preoperative radiotherapy of rectal cancer may lead to a change in staging and target volume delineation. Stage variation was observed in 12% of cases and a change of treatment intent in 4%. The GTV and CTV changed significantly, with a mean increase in size of 25% and 4%, respectively. |
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Authors:
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Maria Chiara Bassi; Lucia Turri; Gianmauro Sacchetti; Gianfranco Loi; Barbara Cannillo; Pierdaniele La Mattina; Marco Brambilla; Eugenio Inglese; Marco Krengli |
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Publication Detail:
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Type: Evaluation Studies; Journal Article Date: 2007-10-10 |
Journal Detail:
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Title: International journal of radiation oncology, biology, physics Volume: 70 ISSN: 0360-3016 ISO Abbreviation: Int. J. Radiat. Oncol. Biol. Phys. Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-03-31 Completed Date: 2008-06-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603616 Medline TA: Int J Radiat Oncol Biol Phys Country: United States |
Other Details:
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Languages: eng Pagination: 1423-6 Citation Subset: IM |
Affiliation:
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Department of Radiotherapy, University of Piemonte Orientale, Novara, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Body Burden Female Fluorodeoxyglucose F18 / diagnostic use* Humans Liver Neoplasms / secondary Lymphatic Metastasis / radiography, radionuclide imaging Male Middle Aged Neoplasm Staging / methods Positron-Emission Tomography / methods* Radiopharmaceuticals / diagnostic use* Radiotherapy, Conformal Rectal Neoplasms* / pathology, radiography, radionuclide imaging Tomography, X-Ray Computed / methods* |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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