| FDG-PET/CT imaging in assessing mucin-producing non-small cell lung cancer with pathologic correlation. | |
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MedLine Citation:
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PMID: 20306161 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The objective of this study was to describe the PET/CT findings of mucin-producing non-small cell lung cancer (NSCLC) and how those findings are associated with pathology. METHODS: A review of all patients with FDG-PET/CT identified 11 patients with histopathologically confirmed mucin-producing NSCLC; 3 mucinous bronchioloalveolar carcinoma (mBAC), 5 mixed-type adenocarcinoma with prominent mucinous BAC pattern (ADENO + mBAC), and 3 mixed-type adenocarcinoma with mucin production (ADENO + MUCIN) in our institute. RESULTS: Among 11 patients, only 2 lesions (18%) evidenced positive PET results for standardized uptake value (SUV) of 3.5 (by ROC analysis) whereas all cases were detected correctly at CT. The mean SUV was 2.0 in the 9 lesions not detected and 2.5 in all cases. The mean SUV of pure mBAC was 1.93, that of mucin-producing adenocarcinoma was 2.69 without a significant difference (p = 0.279). No significant correlations between tumor size or stage and SUV were determined. CONCLUSIONS: PET/CT for SUV is limited in the detection of mucin-producing NSCLC. Therefore, the CT component of PET/CT may allow for significantly improved sensitivity and help to reduce delayed diagnose. The SUV in mBACs were lower than the other types of mucin-producing adenocarcinoma; however, we determined no significant difference to exist between the SUVs of two groups of lung cancer. |
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Authors:
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Sung Shine Shim; Joungho Han |
Publication Detail:
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Type: Journal Article Date: 2010-03-20 |
Journal Detail:
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Title: Annals of nuclear medicine Volume: 24 ISSN: 1864-6433 ISO Abbreviation: Ann Nucl Med Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-15 Completed Date: 2010-09-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8913398 Medline TA: Ann Nucl Med Country: Japan |
Other Details:
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Languages: eng Pagination: 357-62 Citation Subset: IM |
Affiliation:
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Department of Radiology, Center for Imaging Science, Ewha Medical Center, Ewha Medical Research Institute, Ewha Womans University School of Medicine, Mokdong Hospital, Mok 5-dong, Yangcheon-gu, Seoul, 158-710, Korea. sinisim@ewha.ac.kr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Carcinoma, Non-Small-Cell Lung / diagnosis*, metabolism, pathology* Female Fluorodeoxyglucose F18 / diagnostic use* Humans Image Interpretation, Computer-Assisted Lung Neoplasms / diagnosis*, metabolism, pathology* Male Middle Aged Mucins / metabolism* Positron-Emission Tomography* Retrospective Studies Tomography, X-Ray Computed* |
| Chemical | |
Reg. No./Substance:
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0/Mucins; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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