| FDG-PET scan in potentially operable non-small cell lung cancer: do anatometabolic PET-CT fusion images improve the localisation of regional lymph node metastases? The Leuven Lung Cancer Group. | |
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MedLine Citation:
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PMID: 9799345 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exact localisation of thoracic lymph nodes (LNs) on fluorine-18 fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) can be hampered by the paucity of anatomical landmarks. In non-small cell lung cancer (NSCLC) patients referred for locoregional LN staging, we prospectively examined to what extent localisation of LNs at PET reading could be improved by visual correlation with computed tomography (CT), or by anatometabolic PET+CT fusion images. Fifty-six patients with potentially operable NSCLC underwent CT, PET and surgical staging. Prospective reading was performed for CT, PET without CT, PET+CT visual correlation and PET+CT fusion. Reading was blinded to surgical pathology data and noted on a standard LN map. Surgical staging was available for 493 LN stations. In the evaluation per individual LN station, CT was accurate in 87%, PET in 91% and visual correlation and fusion in 93%. In the identification of the nodal stage, CT was correct in 28/56 patients (50%), PET in 37/56 (66%), visual correlation in 40/56 (71%), and fusion in 41/56 (73%). It is concluded that in the exact localisation of metastatic thoracic LNs, the accuracy of reading of PET is increased if the PET images can be visually correlated with CT images. PET+CT anatometabolic fusion images add only a marginal benefit compared with visual correlation. |
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Authors:
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J F Vansteenkiste; S G Stroobants; P J Dupont; P R De Leyn; W F De Wever; E K Verbeken; J L Nuyts; F P Maes; J G Bogaert |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: European journal of nuclear medicine Volume: 25 ISSN: 0340-6997 ISO Abbreviation: Eur J Nucl Med Publication Date: 1998 Nov |
Date Detail:
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Created Date: 1999-01-06 Completed Date: 1999-01-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7606882 Medline TA: Eur J Nucl Med Country: GERMANY |
Other Details:
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Languages: eng Pagination: 1495-501 Citation Subset: IM |
Affiliation:
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Department of Pulmonology/Respiratory Oncology, University Hospital Gasthuisberg, Catholic University Leuven, Belgium. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Carcinoma, Non-Small-Cell Lung / radiography*, radionuclide imaging* Double-Blind Method Fluorodeoxyglucose F18 / diagnostic use* Humans Image Processing, Computer-Assisted Lung Neoplasms / radiography*, radionuclide imaging* Lymphatic Metastasis / radionuclide imaging Mediastinal Neoplasms / secondary Middle Aged Radiopharmaceuticals / diagnostic use* Tomography, Emission-Computed Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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