| FDG-PET and CT patterns of bone metastases and their relationship to previously administered anti-cancer therapy. | |
| | |
MedLine Citation:
|
PMID: 16791597 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To assess (18)F-fluorodeoxyglucose (FDG) uptake in bone metastases in patients with and without previous treatment, and compare positive positron emission tomography (PET) with osteolytic or osteoblastic changes on computed tomography (CT). METHODS: One hundred and thirty-one FDG-PET/CT studies were reviewed for bone metastases. A total of 294 lesions were found in 76 patients, 81 in untreated patients and 213 in previously treated patients. PET was assessed for abnormal FDG uptake localised by PET/CT to the skeleton. CT was evaluated for bone metastases and for blastic or lytic pattern. The relationship between the presence and pattern of bone metastases on PET and CT, and prior treatment was statistically analysed using the chi-square test. RESULTS: PET identified 174 (59%) metastases, while CT detected 280 (95%). FDG-avid metastases included 74/81 (91%) untreated and 100/213 (47%) treated lesions (p<0.001). On CT there were 76/81 (94%) untreated and 204/213 (96%) treated metastases (p NS). In untreated patients, 85% of lesions were seen on both PET and CT (26 blastic, 43 lytic). In treated patients, 53% of lesions were seen only on CT (95 blastic, 18 lytic). Of the osteoblastic metastases, 65/174 (37%) were PET positive and 98/120 (82%), PET negative (p<0.001). CONCLUSION: The results of the present study indicate that when imaging bone metastases, prior treatment can alter the relationship between PET and CT findings. Most untreated bone metastases are PET positive and lytic on CT, while in previously treated patients most lesions are PET negative and blastic on CT. PET and CT therefore appear to be complementary in the assessment of bone metastases. |
| | |
Authors:
|
Ora Israel; Anat Goldberg; Alicia Nachtigal; Daniela Militianu; Rachel Bar-Shalom; Zohar Keidar; Ignac Fogelman |
Related Documents
:
|
10742677 - Clinical utility of fdg-pet in detecting head and neck tumors. a comparison of diagnost... 17513817 - Imaging in local staging of gastric cancer: a systematic review. 11150767 - 10. positron emission tomography in the presurgical evaluation of patients with resecta... 18037877 - Extensive tubercular neck lymphadenopathy in a man with early-stage tongue cancer. 11275247 - Utility of computed tomographic enteroclysis for the general surgeon(1). 9280267 - Arthritic temporomandibular joint: correlation of macromolecular contrast-enhanced mr i... |
Publication Detail:
|
Type: Clinical Trial; Journal Article Date: 2006-06-22 |
Journal Detail:
|
Title: European journal of nuclear medicine and molecular imaging Volume: 33 ISSN: 1619-7070 ISO Abbreviation: Eur. J. Nucl. Med. Mol. Imaging Publication Date: 2006 Nov |
Date Detail:
|
Created Date: 2006-10-24 Completed Date: 2007-05-01 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101140988 Medline TA: Eur J Nucl Med Mol Imaging Country: Germany |
Other Details:
|
Languages: eng Pagination: 1280-4 Citation Subset: IM |
Affiliation:
|
Department of Nuclear Medicine, Rambam Health Care Campus, Haifa, 35254, Israel. o_israel@rambam.health.gov.il |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Antineoplastic Agents / administration & dosage* Bone Neoplasms / diagnosis*, drug therapy, secondary* Bone and Bones / drug effects*, radiography, radionuclide imaging Female Fluorodeoxyglucose F18 / diagnostic use* Humans Male Middle Aged Positron-Emission Tomography / methods* Radiopharmaceuticals / diagnostic use Reproducibility of Results Sensitivity and Specificity Tomography, X-Ray Computed / methods* |
| Chemical | |
Reg. No./Substance:
|
0/Antineoplastic Agents; 0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intracoronary beta-brachytherapy using a rhenium-188 filled balloon catheter in restenotic lesions o...
Next Document: Alphavbeta3-integrin imaging: a new approach to characterise angiogenesis?