Document Detail


FADS gene polymorphisms confer the risk of coronary artery disease in a Chinese Han population through the altered desaturase activities: based on high-resolution melting analysis.
MedLine Citation:
PMID:  23383292     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We explored the desaturase activities and the correlation of fatty acid desaturases (FADS) gene single nucleotide polymorphisms (SNPs) with plasma fatty acid in coronary artery disease (CAD) patients in a Chinese Han population.
METHODS: Plasma fatty acids were measured by gas chromatography in CAD patients (n = 505) and a control group (n = 510). Five SNPs in the FADS gene were genotyped with high-resolution melting (HRM) methods.
RESULTS: After adjustment, D6D activity, assessed as arachidonic acid (AA, C20:4n-6)/linoleic acid (LA, C18:2n-6), was higher in CAD patients (p<0.001). D9D activity, which was estimated as the ratio of palmitoleic acid (C16:1)/palmitic acid (C16:0) or oleic acid (C18:1n-9) to stearic acid (C18:0), was also increased (p<0.001). The genotype distributions of rs174537 G>T and rs174460 C>T were different between the two groups. The rs174537 T allele was associated with a lower risk of CAD [OR 0.743, 95% CI (0.624, 0.884), p = 0.001]. Carriers of the rs174460 C allele were associated with a higher risk of CAD [OR 1.357, 95% CI (1.106, 1.665), p = 0.003].
CONCLUSIONS: We firstly report that the rs174460 C allele is associated with a higher risk of CAD, and confirm that the rs174537 T allele is associated with a lower risk of CAD. Our results indicate that FADS gene polymorphisms are likely to influence plasma fatty acid concentrations and desaturase activities.
Authors:
Si-Wei Li; Kun Lin; Pei Ma; Zhen-Lu Zhang; Yi-Dan Zhou; Shuang-Yan Lu; Xin Zhou; Song-Mei Liu
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-31
Journal Detail:
Title:  PloS one     Volume:  8     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2013  
Date Detail:
Created Date:  2013-02-05     Completed Date:  2013-07-17     Revised Date:  2013-08-20    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e55869     Citation Subset:  IM    
Affiliation:
Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People's Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Aged
Asian Continental Ancestry Group / genetics*
Case-Control Studies
China
Coronary Artery Disease / genetics*
Fatty Acid Desaturases / blood,  genetics*,  metabolism*
Fatty Acids / blood,  metabolism
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Linkage Disequilibrium
Male
Middle Aged
Multigene Family / genetics
Polymorphism, Single Nucleotide*
Chemical
Reg. No./Substance:
0/Fatty Acids; EC 1.14.19.-/Fatty Acid Desaturases
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