| FABP4 is a candidate marker of cerebellar liponeurocytomas. | |
| | |
MedLine Citation:
|
PMID: 22476608 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cerebellar liponeurocytoma (cLPN) is a very rare central nervous system (CNS) tumour recently recognized as a clinical and pathological entity distinct from medulloblastoma (MB), and included in the WHO classification of CNS tumours under the heading "glioneuronal tumours". cLPN typically develop in adult age and have a favourable prognosis compared with MB. In this work, we reviewed the clinical and neuroradiological data of two novel cases of adult cLPN diagnosed at our institution; one patient developed distant metastases. We tried to identify novel molecular markers for this malignancy. We found that the transcription factor NEUROG1 (but not ATOH1) is expressed in cLPN, unlike normal adult cerebellum, and that fatty acid binding protein 4 (FABP4), typically found in adipocytes, is significantly overexpressed compared with both normal adult cerebellum and human MB. These findings suggest cLPN occur as a result of transformation of cerebellar progenitors, which are distinct from cerebellar granule progenitors, and aberrantly differentiate into adipocyte-like tumour cells. They also suggest that analysis of FABP4 expression is of help to differentiate cLPN from MB. |
| | |
Authors:
|
Elena Anghileri; Marica Eoli; Rosina Paterra; Paolo Ferroli; Bianca Pollo; Valeria Cuccarini; Emanuela Maderna; Giovanni Tringali; Marco Saini; Ettore Salsano; Gaetano Finocchiaro |
Related Documents
:
|
20080968 - Betapix up-regulates na+/h+ exchanger 3 through a shank2-mediated protein-protein inter... 16511988 - Heterologous expression systems for studying placental transporters. 9716368 - Long-term effects on serotonin transporter mrna expression of chronic neonatal exposure... 22467218 - Growth hormone synergizes with bmp9 in osteogenic differentiation by activating the jak... 10394638 - High-fluence blue light stimulates transcription from a higher plant chloroplast psba p... 19736548 - Neuropilin-1 and neuropilin-2 are differentially expressed in human proteinuric nephrop... |
Publication Detail:
|
Type: Case Reports; Journal Article Date: 2012-04-03 |
Journal Detail:
|
Title: Journal of neuro-oncology Volume: 108 ISSN: 1573-7373 ISO Abbreviation: J. Neurooncol. Publication Date: 2012 Jul |
Date Detail:
|
Created Date: 2012-06-06 Completed Date: 2012-10-16 Revised Date: 2012-11-30 |
Medline Journal Info:
|
Nlm Unique ID: 8309335 Medline TA: J Neurooncol Country: United States |
Other Details:
|
Languages: eng Pagination: 513-9 Citation Subset: IM |
Affiliation:
|
Unit of Molecular Neuro-oncology, Fondazione IRCCS C. Besta, Via Celoria 11, 20133, Milan, Italy. anghileri.e@istituto-besta.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Cerebellar Neoplasms / diagnosis*, genetics, metabolism Diagnosis, Differential Fatty Acid-Binding Proteins / genetics, metabolism* Female Humans Immunoenzyme Techniques Lipoma / diagnosis*, genetics, metabolism Middle Aged Neurocytoma / diagnosis*, genetics, metabolism Prognosis RNA, Messenger / genetics Real-Time Polymerase Chain Reaction Retrospective Studies Reverse Transcriptase Polymerase Chain Reaction Tumor Markers, Biological / genetics, metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/FABP4 protein, human; 0/Fatty Acid-Binding Proteins; 0/RNA, Messenger; 0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intervention characteristics that facilitate return to work after sickness absence: a systematic lit...
Next Document: An early attentional bias to BEGIN-stimuli of the smoking ritual is accompanied with mesocorticolimb...