Document Detail


F2-isoprostanes in kidney transplant patients: relationship with inflammatory markers.
MedLine Citation:
PMID:  16386558     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This prospective study evaluated the relationship between inflammation and oxidative stress in a group of dialysis patients just before and 3 months after kidney transplantation and compared the results with a control group of healthy subjects. The oxidative stress markers determined were different F2-isoprostane isomers. The inflammatory markers included C-reactive protein, interleukin-6, tumor necrosis factor-alpha, and pregnancy-associated plasma protein A. Forty-three patients were the study group and 50 healthy subjects from a hospital blood bank as controls. The results showed levels of inflammatory and oxidative stress markers to be higher in the dialysis patients than in the control group, although they improved following kidney transplantation. Finally, significant correlations were observed between F2-isoprostane isomers and inflammatory markers.
Authors:
R Lauzurica; M C Pastor; B Bayés; J M Hernández; J Bonet; M A Llopis; L Carrera; R Romero
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Transplantation proceedings     Volume:  37     ISSN:  0041-1345     ISO Abbreviation:  Transplant. Proc.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2006-01-02     Completed Date:  2006-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0243532     Medline TA:  Transplant Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3842-3     Citation Subset:  IM    
Affiliation:
Servicios de Nefrología y Bioquimica, Badalona, Spain. rlauzu@ns.hugtip.scs.es
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biological Markers / blood
C-Reactive Protein / metabolism*
F2-Isoprostanes / blood*
Female
Follow-Up Studies
Humans
Inflammation / blood*
Interleukin-6 / blood
Kidney Transplantation / physiology*
Male
Middle Aged
Oxidative Stress
Postoperative Complications / blood*
Prospective Studies
Tumor Necrosis Factor-alpha / metabolism
Chemical
Reg. No./Substance:
0/Biological Markers; 0/F2-Isoprostanes; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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