Document Detail

F-wave characteristics as surrogate markers of spasticity in patients with secondary progressive multiple sclerosis.
MedLine Citation:
PMID:  20505376     Owner:  NLM     Status:  MEDLINE    
We sought to identify significant ulnar nerve conduction abnormalities and also to detect ulnar F-wave variable changes in patients with secondary progressive multiple sclerosis (MS). Conventional conduction study was performed unilaterally to ulnar nerves of eight men and 12 women with secondary progressive MS (mean age, 47.5 +/- 6.6 years), having spastic hemiparesis and hand spasticity. A series of 40 electrical stimuli were also delivered to their ulnar nerves unilaterally so as to obtain F waves. The side of examination was ipsilateral to the side of spastic paresis. The following F-wave variables were estimated: F-wave persistence, latency, amplitude, duration, and F chronodispersion. Ten patients with remitting-relapsing MS without any evidence of hand spasticity and 20 age- and gender-matched healthy volunteers served as controls. Motor and sensory conduction study was normal in all participants. The F-wave persistence, latency, and duration parameters and also the F chronodispersion were comparable between groups. The mean and maximum F-wave amplitude values (P = 0.005) and the F mean/M (P = 0.001) and F maximal/M (P = 0.001) ratios were significantly higher than those of controls. Finally, the F-wave amplitude parameters in patients with secondary progressive MS significantly correlated with the degree of spasticity and the duration of disease. Significant amplitude F-wave abnormalities occurred in patients with secondary progressive MS and hand spasticity, emphasizing the contribution of upper motor neurons damage in the genesis of F waves.
Andreas A Argyriou; Panagiotis Karanasios; Alexandra Makridou; Nicolaos Makris
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society     Volume:  27     ISSN:  1537-1603     ISO Abbreviation:  J Clin Neurophysiol     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-05-27     Completed Date:  2010-09-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8506708     Medline TA:  J Clin Neurophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  120-5     Citation Subset:  IM    
EMG Laboratory, Department of Neurology, Saint Andrew's State General Hospital of Patras, Patras, Greece.
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MeSH Terms
Case-Control Studies
Hemiplegia / complications,  diagnosis,  physiopathology
Middle Aged
Multiple Sclerosis, Chronic Progressive / complications,  diagnosis*,  physiopathology*
Multiple Sclerosis, Relapsing-Remitting / complications,  diagnosis,  physiopathology
Muscle Spasticity / complications,  diagnosis*,  physiopathology*
Neural Conduction
Time Factors
Ulnar Nerve / physiopathology*
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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