Document Detail

F-cells in the adult: normal values and levels in individuals with hereditary and acquired elevations of Hb F.
MedLine Citation:
PMID:  1100141     Owner:  NLM     Status:  MEDLINE    
Specific antibodies to human fetal hemoglobin were prepared and, after conjugation with a fluorescent dye, were used to determine the distribution of Hb F-containing cells in blood smears from normal adults and individuals with hereditary and acquired conditions associated with abnormal levels of Hb F. The mean proportion of F-cells in normal persons was 2.7% +/- 1.4%, with a range of 0.5%-7.0%. Proportions of F-cells were increased in persons with several acquired and inherited disorders that are associated with an increased percentage of Hb F in hemolysates. A strong linear correlation between the amount of Hb F and proportion of F-cells was observed. This technique may prove useful in studies of a variety of disorders associated with Hb F elevations and also in investigations of the mechanisms controlling the transition from fetal to adult hemoglobin during the course of human development.
W G Wood; G Stamatoyannopoulos; G Lim; P E Nute
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Blood     Volume:  46     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  1975 Nov 
Date Detail:
Created Date:  1975-12-28     Completed Date:  1975-12-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  671-82     Citation Subset:  AIM; IM    
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MeSH Terms
Anemia, Aplastic / blood
Anemia, Sickle Cell / blood
Fetal Hemoglobin / analysis*
Fluorescent Antibody Technique
Hemoglobinopathies / blood,  genetics*
Immunization Schedule
Thalassemia / blood
Reg. No./Substance:
0/Antibodies; 9034-63-3/Fetal Hemoglobin

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