| Ezetimibe-related myopathy: A systematic review. | |
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MedLine Citation:
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PMID: 21291757 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Ezetimibe is a synthetic 2-azetidinone that inhibits the absorption of sterols, including cholesterol, in the intestine. It is used as monotherapy or in combination with statins to reduce low-density lipoprotein cholesterol (LDL-C). Although extremely well-tolerated, there are reports of myopathy associated with ezetimibe. We performed a PubMed search through April 2008 to identify English language articles examining ezetimibe safety as monotherapy or in combination with other lipid-lowering agents. The incidence of musculoskeletal disorders in clinical trials using ezetimibe alone or in combination with statins is identical to placebo or the statin alone, respectively. We identified only six case reports of possible ezetimibe-associated myopathy. We concluded that ezetimibe neither produces nor exacerbates statin myopathy except, possibly, in rare cases. |
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Authors:
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Hanna Slim; Paul D Thompson |
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Publication Detail:
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Type: Journal Article Date: 2008-08-15 |
Journal Detail:
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Title: Journal of clinical lipidology Volume: 2 ISSN: 1933-2874 ISO Abbreviation: J Clin Lipidol Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2011-02-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101300157 Medline TA: J Clin Lipidol Country: United States |
Other Details:
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Languages: eng Pagination: 328-34 Citation Subset: - |
Affiliation:
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Hospital of Saint Raphael, New Haven, CT, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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