| Ezetimbe as potential treatment for cholesterol gallstones: the need for clinical trials. | |
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MedLine Citation:
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PMID: 20355232 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Obesity is associated with insulin resistance, non-alcoholic fatty liver disease (NAFLD) and gallstones.High fat diets (unsaturated fats) rich in cholesterol have been demonstrated to produce not only gallstones but also NAFLD and insulin resistance. Interestingly, a high incidence of gallstones is being reported in association with insulin resistance and NAFLD. Laparoscopic cholecystectomy is the best definitive therapy for symptomatic gallbladder disease. Ezetimibe is a drug that inhibits the absorption of both dietary and biliary cholesterol in the small intestine. Importantly, ezetimibe showed potential benefit not only in treating and preventing gallstones but also in insulin resistance and NAFLD. Further studies are required before the use of ezetimibe for the treatment of gallstones can be advocated. |
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Authors:
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Mohamed H Ahmed |
Publication Detail:
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Type: Editorial |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 16 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-31 Completed Date: 2010-07-29 Revised Date: 2010-09-28 |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 1555-7 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticholesteremic Agents / therapeutic use* Azetidines / therapeutic use* Cholesterol / metabolism* Clinical Trials as Topic Diet Drug Evaluation, Preclinical / methods Fatty Liver / drug therapy Gallstones / drug therapy* Humans Insulin Resistance Intestine, Small / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Azetidines; 163222-33-1/ezetimibe; 57-88-5/Cholesterol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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