Document Detail


Eyeball retraction latency in the conscious rabbit measured with a new photodiode technique.
MedLine Citation:
PMID:  6727420     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new technique is described for accurate, reliable measurement of eyeball retraction in the rabbit. A narrow film strip, on which a linear light intensity grating has been exposed, is attached to a contact lens which is placed on the animal's cornea. The other end of the intensity grating slides between a photodiode and an LED. The contact lens-film grating assembly moves freely with eyeball retraction and relaxation, causing changes in photodiode output. This device appears to be well tolerated by the animal. Large amplitude eyeball retractions occur in response to air puff stimulation directed at the upper or lower eyelid and to periorbital shock. Average eye retraction latency to stimulation of the abducens (VI) nerve with a chronically implanted stimulating electrode was 5.3 ms (S.D. = 0.75 ms) in the conscious rabbit as measured with our device. Latency to periorbital electrical shock was 9.3 ms (S.D. = 2.1 ms). Eye retraction latency decreased with increasing shock amplitudes. Rabbits readily acquired classically conditioned eyeball retractions, monitored with this device, when a white noise auditory stimulus was paired with an air puff directed at the eyelid.
Authors:
K J Quinn; P R Kennedy; C Weiss; J F Disterhoft
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neuroscience methods     Volume:  10     ISSN:  0165-0270     ISO Abbreviation:  J. Neurosci. Methods     Publication Date:  1984 Jan 
Date Detail:
Created Date:  1984-06-25     Completed Date:  1984-06-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7905558     Medline TA:  J Neurosci Methods     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  29-39     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Abducens Nerve / physiology
Animals
Axons / physiology
Conditioning, Eyelid* / physiology
Electric Stimulation
Neural Conduction
Neurophysiology / instrumentation*
Rabbits
Reaction Time* / physiology
Grant Support
ID/Acronym/Agency:
NIH 2 S07 RR05370/RR/NCRR NIH HHS; NIH NS17489/NS/NINDS NIH HHS; NIMH T32-MH16097/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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